| Nintendo 3DS cart. |  Simple DL Series Vol 12 - The Dasshutsu Game - Kiken na 5tsu no Misshitsu Model CTR-JD4J-JPN | 201? | Nintendo Co., Ltd. Japan |
| Gun game | Sky Hawk | 197? | Nintendo Co., Ltd. Japan |
| Arcade Video game | Sky Skipper | 1981 | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. |  Smash Controller App Model CTR-KXCP-EUR | 201? | Nintendo Co., Ltd. Japan |
| Nintendo Famicom disk | Smash Ping Pong Model FMC-PPN | 1987 | Nintendo Co., Ltd. Japan |
| Coin-op Misc. game | Smashmatic | 1975 | Nintendo Co., Ltd. Japan |
| Nintendo Switch cart. | Snipperclips Plus - Cut It Out, Together! Model LA-H-AEXYA-UKV | 2017 | Nintendo Co., Ltd. Japan |
| Handheld game | Snoopy Tennis Model SP-30 | 1982 | Nintendo Co., Ltd. Japan |
| Tabletop game | Snoopy Model SM-73 | 1983 | Nintendo Co., Ltd. Japan |
| Handheld game | Snoopy Model SM-91 | 1983 | Nintendo Co., Ltd. Japan |
| Nintendo Pokémon Mini game | Snorlax's Lunch Time | 2003 | Nintendo Co., Ltd. Japan |
| Nintendo Famicom disk |  Soccer Model FMC-SCC | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo Famicom cart. | Soccer Model HVC-SC | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Soccer Model NES-SC-NOE | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Jetman - Hunt for the Golden Warpship Model NES-LJ-EEC | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Jetman - Hunt for the Golden Warpship Model NES-LJ-UKV | 1990 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solar Jetman - La Chasse au Vaisseau d'Or Model NES-LJ-FRA | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo Game Boy Cart. | Solar Striker Model DMG-SSA | 1990 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solstice - La Quete du Sceptre de Denunos Model NES-LX-FRA | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo NES cart. | Solstice - The Quest for the Staff of Demnos Model NES-LX-FRG | 1991 | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. | Sonic Lost World Model CTR-ARVP-EUR | 201? | Nintendo Co., Ltd. Japan |
| Nintendo GameCube disc | SoulCalibur II Model DOL-GRSP-EUR | 2003 | Nintendo Co., Ltd. Japan |
| Nintendo Super NES cart. |  Sound Factory | 1993 | Nintendo Co., Ltd. Japan |
| Nintendo GBA cart. | Soundvoyager bit Generations Model AGB-BVGJ-JPN | 2006 | Nintendo Co., Ltd. Japan |
| Nintendo Super Famicom cart. | Space Bazooka Model SHVC-BT | 1993 | Nintendo Co., Ltd. Japan |
| Arcade Video game | Space Fever | 1979 | Nintendo Co., Ltd. Japan |
| Arcade Video game | Space Fever High Splitter | 1979 | Nintendo Co., Ltd. Japan |
| Arcade Video game | Space Firebird Cocktail Table model | 1980 | Nintendo Co., Ltd. Japan |
| Arcade Video game | Space Firebird Upright model | 1980 | Nintendo Co., Ltd. Japan |
| Nintendo Super NES cart. | Space Invaders - The Original Game Model SNSP-IC-AUS | 1997 | Nintendo Co., Ltd. Japan |
| Nintendo Game Boy Cart. | Space Invaders Model DMG-SP-AUS | 1994 | Nintendo Co., Ltd. Japan |
| Nintendo Game Boy Cart. | Space Invaders Model DMG-SP-UKV | 1994 | Nintendo Co., Ltd. Japan |
| Arcade Video game | Space Launcher | 1979 | Nintendo Co., Ltd. Japan |
| Nintendo Virtual Boy cart. | Space Pinball | 1995 | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. | Sparkle Snapshots 3D Model CTR-JCVP-EUR | 201? | Nintendo Co., Ltd. Japan |
| Nintendo Famicom cart. | Spartan X Model HVC-SX P | 1985 | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. | SpeedThru - Potzol’s Puzzle Model CTR-JELP-EUR | 201? | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. | Spirit Camera - The Cursed Memoir Model CTR-ALCP-EUR | 201? | Nintendo Co., Ltd. Japan |
| Handheld game | Spitball Sparky Model BU-201 | 1984 | Nintendo Co., Ltd. Japan |
| Nintendo 3DS cart. | Splash or Crash Model CTR-JHSP-EUR | 201? | Nintendo Co., Ltd. Japan |
