| Pinball |  Sky Fly | 1978 | Europlay |
| Arcade Video game | Sky Raider | 1978 | Atari, Inc. CA, USA |
| Arcade Video game | Skydiver | 1978 | Atari, Inc. CA, USA |
| BASIC soft. type-in | Slalom | 1978 | Workman Publishing NY, USA |
| Atari 2600 cart. | Slot Machine Model CX2653 | 1978 | Atari, Inc. CA, USA |
| Atari 2600 cart. |  Slot Racers Model CX2606P | 1978 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Slot Racers Model CX2606 | 1978 | Atari, Inc. CA, USA |
| Apple I soft. | Slots P | 1978 | Unknown |
| BASIC soft. type-in | Slots | 1978 | Workman Publishing NY, USA |
| Arcade Video game | Smokey Joe | 1978 | Atari, Inc. CA, USA |
| TRS-80 cass. | Snake Eggs | 1978 | 80-NW Publishing Co. |
| Handheld game | Soccer Model 2678 | 1978 | Mattel Electronics Mattel, Inc. |
| Apple II cass. | Solo Race | 1978 | Systems Design Lab |
| Texas Instruments SR-52 soft. | Son-in-Law of Submarine | 1978 | 1001001, Inc. |
| Commodore PET cass. | Soundware Backgammon | 1978 | Cap Electronics |
| Commodore PET cass. | Soundware Checkers | 1978 | Cap Electronics |
| Toshiba Visicom cart. | Space Command Model CAS-160 P | 1978 | Toshiba Corp. |
| Commodore PET cass. | Space Fight | 1978 | Commodore Business Machines, Inc. |
| Arcade Video game | Space Fighter | 1978 | Data East Corp. Japan |
| Pinball | Space Gambler | 1978 | Playmatic, S.A. Spain |
| Apple II cass. | Space Games-1 Model CS-4001 | 1978 | Creative Computing Soft. |
| Arcade Video game | Space Invaders | 1978 | Taito Corp. Japan |
| Arcade Video game | Space Invaders Model 739 | 1978 | Midway Mfg. Co. Schiller Park, IL, USA |
| Arcade Video game | Space Invaders Model 775 | 1978 | Midway Mfg. Co. Schiller Park, IL, USA |
| Arcade Video game | Space Invaders Trimline model | 1978 | Taito America Corp. Elk Grove Village, IL, USA |
| Arcade Video game | Space King | 1978 | Leijac Corp. Japan |
| Apple II cass. | Space Maze Model ADG0104 | 1978 | Powersoft, Inc. |
| Pinball | Space Riders | 1978 | Atari, Inc. CA, USA |
| Arcade Video game | Space Ship | 1978 | Leijac Corp. Japan |
| Arcade Video game | Space Ship | 1978 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Space Walk | 1978 | Midway Mfg. Co. Schiller Park, IL, USA |
| Atari 2600 cart. | Space War Model CX2604P | 1978 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Space War Model CX2604 | 1978 | Atari, Inc. CA, USA |
| Arcade Video game | Space Wars | 1978 | Sonic, S.A. Madrid, Spain |
| Arcade Video game | Space Wars | 1978 | Taito Corp. Japan |
| Apple II cass. | Space Wars + Apple Trek | 1978 | Apple Computer, Inc. |
| Hanimex MPT-02 cart. | Spacewar Intercept Model MG-212 | 1978 | Hanimex |
| Handheld game | Speak & Spell | 1978 | Texas Instruments |
| Pinball | Spectra IV | 1978 | Valley Recreation Products, Inc. Bay City, MI, USA |
| Magnavox Odyssey² cart. | Speedway + Spin-Out + Crypto-logic Model AC9400 | 1978 | Magnavox Co., The Fort Wayne, IN, USA |
