| Commodore PET cass. |  Santa Paravia and Fiumaccio | 1978 | Folklife Terminal Club |
| TRS-80 type-in | Santa Paravia en Fiumaccio | 1978 | SoftSide Publications, Inc. |
| CP/M 8in. disk | Sargon | 1978 | Hayden Book Co. |
| TRS-80 cass. | Sargon P | 1978 | Hayden Soft. |
| CP/M 8in. disk | Sargon II | 1978 | Spracklen & Spracklen |
| Pinball | Satellite | 1978 | CEA Electronics Bologna, Italy |
| Apple II cass. | Saucer Invasion Model ADG0102 | 1978 | Powersoft, Inc. |
| Apple II cass. | Save-a-Sketch | 1978 | Innovative Computer |
| Apple II cass. | Save-a-Story | 1978 | Innovative Computer |
| Tabletop game | Scrabble Lexor | 1978 | Selchow & Righter Co. Bay Shore, NY, USA |
| Tabletop game | Scrabble Sensor - Electronic Word Game | 1978 | Selchow & Righter Co. Bay Shore, NY, USA |
| Arcade Video game | Scramble | 1978 | Vectorbeam Union City, CA, USA |
| Texas Instruments TI-57 soft. | Scrambled Eggs | 1978 | Texas Instruments |
| Bally Astrocade type-in | Scribbler | 1978 | Bally Mfg. Co. Chicago, IL, USA |
| Bally Astrocade type-in | Scroll Two | 1978 | Bally Mfg. Co. Chicago, IL, USA |
| Arcade Video game | Sea Wolf II Model 625 | 1978 | Midway Mfg. Co. Schiller Park, IL, USA |
| Commodore PET cass. | Seawolf | 1978 | Creative Soft. |
| Bally Astrocade cart. | Seawolf + Missile Model 2002 | 1978 | Bally Mfg. Co. Chicago, IL, USA |
| Arcade Video game | Secret Base | 1978 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Secret War | 1978 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game |  Seesaw Jump Cocktail model | 1978 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | Seesaw Jump Upright model | 1978 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Redemption mechanical game | Sekai Isshuu Game | 1978 | Kakizaki Japan |
| CP/M 8in. disk | Sensational Software: Games-1 | 1978 | Creative Computing Soft. |
| CP/M 8in. disk | Sensational Software: Games-2 | 1978 | Creative Computing Soft. |
| Arcade Video game | Shark Treasure | 1978 | Universal Co., Ltd Tokyo, Japan |
| HP-25 soft. | Shooting Gallery | 1978 | Fiveash, John |
| Interact Family Computer cass. | Showdown | 1978 | Interact Electronics |
| Arcade Video game | Shuffleboard Model 643 | 1978 | Midway Mfg. Co. Schiller Park, IL, USA |
| Apple II cass. | Side Show - Six Games | 1978 | MUSE Soft. Micro Users Soft. Exchange |
| Handheld game | Simon Model 4850-L1 | 1978 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Texas Instruments TI-57 soft. | SINAM 2-Digit ver. | 1978 | Texas Instruments |
| Texas Instruments TI-57 soft. | SINAM 3-Digit ver. | 1978 | Texas Instruments |
| Pinball | Sinbad EM Model 412 | 1978 | Gottlieb & Co., D. Chicago, IL, USA |
| Pinball | Sinbad SS Model 412 | 1978 | Gottlieb & Co., D. Chicago, IL, USA |
| Commodore PET cass. | Sinners P | 1978 | Computers/Calculators Magazine |
| Pinball | Skateball Model 1150 | 1978 | Bally Mfg. Co. Chicago, IL, USA |
| Pinball | Ski Jump | 1978 | Zaccaria Bologna, Italy |
| Atari 2600 cart. | Sky Diver Model CX2629P | 1978 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Sky Diver Model CX2629 | 1978 | Atari, Inc. CA, USA |
