| PC/MS-Windows CD |  Mahjong Titans | 2006 | Microsoft |
| Nintendo GBA cart. | Mahou Sensei Negima Private Lesson 2 - Ojamashimasuu Parasite de Chuu Model AGB-BNMJ-JPN | 2006 | Marvelous Interactive, Inc. |
| Slot Machine | Maiko | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Pachislot | Maison Ikkoku | 2006 | Olympia Co., Ltd. Japan |
| Pachislot | Maison Ikkoku Alt. Art | 2006 | Olympia Co., Ltd. Japan |
| MSX cart. | Majikazo Hb | 2006 | Lemonize |
| Slot Machine | Major Jackpots | 2006 | IGT International Game Technologies Reno, NV, USA |
| Microsoft XBOX 360 disc | Major League Baseball 2K6 | 2006 | 2K Sports |
| Nintendo GameCube disc | Major League Baseball 2K6 | 2006 | 2K Sports |
| Sony PSP UMD | Makai Senki Disgaea Portable Model ULJM-07155 | 2006 | Nippon Ichi Soft., Inc. Japan |
| Sony PSP UMD | Makai Senki Disgaea Portable Model ULJS-00089 | 2006 | Nippon Ichi Soft., Inc. Japan |
| Slot Machine | Make a Wi$h | 2006 | ID Interactive |
| MSX cart. | Malaika - Prehistoric Quest Hb | 2006 | Karoshi Corp. |
| PC/MS-Windows CD | Mama! Tsuma? | 2006 | Complet's |
| Pachinko | Mangetsunoyoru ni Syoutenshitai | 2006 | Ginza Japan |
| PC/MS-Windows CD | Marc Ecko's Getting Up - Contents Under Pressure | 2006 | Atari Europe S.A.S.U. |
| Nintendo GBA cart. | March of the Penguins Model AGB-BQLE-USA | 2006 | DSI Games |
| Nintendo GBA cart. | March of the Penguins Model AGB-BQLP | 2006 | Zoo Digital Publishing |
| Pachinko | Marine Attack | 2006 | Heiwa Japan |
| MSX cart. | Mars Lander Hb | 2006 | Unknown |
| PC/MS-Windows CD | Marvel - Ultimate Alliance | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Marvel - Ultimate Alliance Model AGB-B4ME-USA | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Marvel - Ultimate Alliance Model AGB-B4MP | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Mattel HyperScan CD | Marvel Heroes | 2006 | Mattel Electronics Mattel, Inc. |
| Sony PlayStation 3 disc | Marvel Ultimate Alliance | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Microsoft XBOX 360 disc | Marvel Ultimate Alliance | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Sony PSP UMD | Marvel Ultimate Alliance | 2006 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Slot Machine | Masked Money | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Masked Warrior | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Sinclair ZX-80 cass. | Master Mind Hb | 2006 | MadAxe |
| Slot Machine | Match Play | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Max Your Edge | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Medal video game | Maximum Gold | 2006 | Unknown Korea |
| MSX cart. | Maze Chase Hb | 2006 | Area 51 |
| Colecovision cart. | Maze Maniac Hb | 2006 | Boyer, Charles-Mathieu |
| Nintendo GBA cart. | Mazes of Fate Model AGB-BFQE-USA | 2006 | O3 Ent. |
| Sony PSP UMD | Me & My Katamari Model ULES-00339 | 2006 | Electronic Arts CA, USA 14633 |
| Sony PSP UMD | Me & My Katamari Model ULUS-10094 | 2006 | NAMCO Bandai Games, Inc. Japan |
| MSX cart. | Mecha Taisen on Planet Oldskool Hb | 2006 | DamageX |
| Sony PSP UMD | Medal of Honor Heroes | 2006 | Electronic Arts CA, USA 14633 |
