| Arcade Video game |  EA Sports Madden NFL Football - Season 2 | 2006 | Global VR San Jose, CA, USA |
| Arcade Video game | EA Sports PGA Tour Golf Team Challenge | 2006 | Global VR San Jose, CA, USA |
| Microsoft XBOX 360 disc | Earth Defense Force 2017 | 2006 | D3 Publisher, Inc. |
| Slot Machine | Eastern Sun | 2006 | IGT International Game Technologies Reno, NV, USA |
| Sinclair ZX Spectrum cass. | Egghead 4 - Egghead Entertains Hb | 2006 | Cronosoft |
| Sinclair ZX Spectrum cass. | Egghead in Space Hb | 2006 | Cronosoft |
| Slot Machine | Egyptian Experience | 2006 | AGI Austrian Gaming Industries Novomatic Group |
| Slot Machine | Egyptian King Classic | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Egyptian Prince | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Egyptian Riches | 2006 | Aruze Corp. Japan |
| Acorn Electron 3.5in. disk | Electron User Group #66 | 2006 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #66 | 2006 | EUG Electron User Group |
| Nintendo DS cart. | Electroplankton Model NTR-ATIE-USA | 2006 | Nintendo of America, Inc. USA 45496 |
| Slot Machine | Eleven Pearls | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| PC/MS-Windows DVD | Elf All Star Datsui-Jan 3 | 2006 | Elf Japan |
| Sinclair ZX Spectrum cass. | Elvin The Elf Hb | 2006 | ZXF |
| Slot Machine | Emerald Butterfly | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Emerald Eyes | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Amstrad CPC 464 disk | En Busca de la Joya Encantada Hb | 2006 | RML Soft |
| Microsoft XBOX 360 disc | Enchanted Arms | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
| Slot Machine | Enchanted Egypt | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Enchanted Island | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Enchanted Jewel | 2006 | AGI Austrian Gaming Industries Novomatic Group |
| Slot Machine | Enchanted Kingdom | 2006 | WMS Gaming, Inc. Chicago, IL, USA |
| Video Slot Machine | Enchanted Lamp | 2006 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Slot Machine | Endspiel | 2006 | Bally Wulff |
| Microsoft XBOX 360 disc | Eragon | 2006 | Vivendi Universal Games, Inc. |
| Sony PSP UMD | Eragon | 2006 | Vivendi Universal Games, Inc. |
| PC/MS-Windows CD | Eragon | 2006 | Sierra Ent., Inc. USA |
| Nintendo GBA cart. | Eragon Model AGB-BENE-USA | 2006 | Vivendi Universal Games, Inc. |
| Nintendo GBA cart. | Eragon Model AGB-BENP | 2006 | Vivendi Universal Games, Inc. |
| VTECH V.Smile cart. | Ernies & Berts Fantastisches Abenteuer | 2006 | VTECH Video Technology, Ltd. |
| PC/MS-Windows CD | Etrom - The Astral Essence | 2006 | Strategy First |
| Slot Machine | Eureka | 2006 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Euro-Bank | 2006 | Mega |
| PC/MS-Windows CD | EverQuest - Prophecy of Ro | 2006 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | EverQuest - The Serpent's Spine | 2006 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | EverQuest II - The Fallen Dynasty | 2006 | Sony Computer Ent. America SCEA CA, USA |
| Sony PSP UMD | Every Extend Extra Model ULUS-10147 | 2006 | Buena Vista Games |
| Sony PSP UMD | Exit Model ULES-00285 | 2006 | Ubisoft Ent. Montreuil sous Bois, France |
