| Nintendo GBA cart. |  Scooby-Doo Unmasked Model AGB-B25E-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | Scooby-Doo Unmasked Model AGB-B25P | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | Scrabble Blast! Model AGB-BLAE-USA | 2005 | DSI Games |
| Nintendo GBA cart. | Scrabble Scramble! | 2005 | Zoo Digital Publishing |
| Nintendo GBA cart. | Screw Breaker - Goushin DoriRureRo Model AGB-V49J-JPN | 2005 | Nintendo Co., Ltd. Japan |
| Nintendo GBA cart. | Sennen Kazoku Model AGB-BKAJ-JPN | 2005 | Nintendo Co., Ltd. Japan |
| Nintendo GBA cart. | Shamu's Deep Sea Adventures Model AGB-BBAE-USA | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Shin Bokura no Taiyou - Gyakushuu no Sabata Model AGB-U33J-JPN | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shin Chan - Aventuras en Cineland Model AGB-BKCS-ESP | 2005 | Atari Interactive, Inc. |
| Nintendo GBA cart. | Shin Sangoku Musou Advance Model AGB-B36J-JPN | 2005 | KOEI Co., Ltd. Japan |
| Nintendo GBA cart. | Shonen Jump's Shaman King - Legacy of the Spirits - Soaring Hawk Model AGB-BHLE-USA | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Shaman King - Legacy of the Spirits - Sprinting Wolf Model AGB-BWSE-USA | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Shaman King - Master of Spirits 2 Model AGB-B2ME-USA | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Shaman King - Master of Spirits Model AGB-BSOP | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh 7 Trials to Glory - World Championship Tournament 2005 Model AGB-BY7E-USA | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh Day of the Duelist - World Championship Tournament 2005 Model AGB-BYOP | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shonen Jump's Yu-Gi-Oh Destiny Board Traveler Model AGB-BYDP | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shrek - Super Slam Model AGB-B4UE-USA | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Shrek - Super Slam Model AGB-B4UP | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Sigma Star Saga Model AGB-B3GE-USA | 2005 | NAMCO, Ltd. Japan |
| Nintendo GBA cart. | Sigma Star Saga Model AGB-B3GP | 2005 | NAMCO, Ltd. Japan |
| Nintendo GBA cart. | Sky Dancers - They Magically Fly! Model AGB-B4DP | 2005 | Crave Ent., Inc. |
| Nintendo GBA cart. | Smashing Drive Model AGB-BSVP | 2005 | Zoo Digital Publishing |
| Nintendo GBA cart. | Snood 2 - On Vacation Model AGB-B2VE-USA | 2005 | DSI Games |
| Nintendo GBA cart. | Snood 2 - On Vacation Model AGB-B2VP | 2005 | Zoo Digital Publishing |
| Nintendo GBA cart. | SpongeBob SquarePants - Lights, Camera, Pants! Model AGB-BQQE-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | SpongeBob SquarePants - Lights, Camera, Pants! Model AGB-BQQP | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. |  SpongeBob SquarePants - The Movie Model AGB-BSNP-EUR | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | Sportsman's Pack Model AGB-B23E-USA | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Spyro - Fusion + Crash Bandicoot - Fusion | 2005 | Vivendi Universal Games, Inc. |
| Nintendo GBA cart. | Spyro - Season of Ice + Crash Bandicoot - The Huge Adventure | 2005 | Sierra Ent., Inc. USA |
| Nintendo GBA cart. | Spyro - Season of Ice + Crash Bandicoot 2 - N-Tranced | 2005 | Vivendi Universal Games, Inc. |
| Nintendo GBA cart. | Spyro 2 - Season of Flame + Crash Nitro Kart | 2005 | Vivendi Universal Games, Inc. |
| Nintendo GBA cart. | Spyro Orange - The Cortex Conspiracy + Crash Bandicoot Purple - Ripto's Rampage Model AGB-B53E-USA | 2005 | Sierra Ent., Inc. USA |
| Nintendo GBA cart. | Spyro Superpack: Spyro - Season of Ice + Spyro - Season of Flame Model AGB-B8SE-USA | 2005 | Vivendi Universal Games, Inc. |
| Nintendo GBA cart. | Star Wars - Episode III - Revenge of the Sith Model AGB-BE3E-USA | 2005 | Ubisoft Ent. Montreuil sous Bois, France |
| Nintendo GBA cart. | Star Wars - Episode III - Revenge of the Sith Model AGB-BE3P | 2005 | Ubisoft Ent. Montreuil sous Bois, France |
| Nintendo GBA cart. | Steel Empire Model AGB-BKTP | 2005 | Zoo Digital Publishing |
| Nintendo GBA cart. | Strawberry Shortcake - Summertime Adventure - Special Edition Model AGB-BQWE-USA | 2005 | Majesco Ent. Co. |
| Nintendo GBA cart. | Street Racing Syndicate Model AGB-BCZE-USA | 2005 | DSI Games |
