| Nintendo GameCube disc |  Scooby-Doo! Unmasked | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo DS cart. | Scooby-Doo! Unmasked Model NTR-ASDE-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | Scrabble Blast! Model AGB-BLAE-USA | 2005 | DSI Games |
| Nintendo GBA cart. | Scrabble Scramble! | 2005 | Zoo Digital Publishing |
| Sony PlayStation 2 disc | Scramble Oretachi Geasen Zoku Model SLPM-62626 | 2005 | Hamster Japan |
| Nintendo GBA cart. | Screw Breaker - Goushin DoriRureRo Model AGB-V49J-JPN | 2005 | Nintendo Co., Ltd. Japan |
| Pachislot | Sea Story | 2005 | Sanyo Japan |
| Video Slot Machine | Sea World | 2005 | Amcoe, Inc. USA |
| PC/MS-Windows CD | Second Sight | 2005 | Codemasters Soft. Co., Ltd., The 015026 |
| Slot Machine | Secret Forest | 2005 | AGI Austrian Gaming Industries Novomatic Group |
| Medal video game | Secret Royal Inspector | 2005 | GM Electronic Co., Ltd. Korea |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.17: Phantasy Star generation-2 Model SLPM-62553 P | 2005 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.18: Dragon Force Model SLPM-65778 P | 2005 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.19: Fighting Vipers Model SLPM-62606 P | 2005 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.20: Space Harrier II - Space Harrier Complete Collection Model SLPM-62691 P | 2005 | SEGA Corp. |
| Sony PlayStation 2 disc | Sega Ages 2500 Vol.23: Sega Memorial Selection Model SLPM-62709 P | 2005 | SEGA Corp. |
| Nintendo DS cart. | Sega Casino | 2005 | SEGA of America, Inc. San Francisco, CA, USA |
| Arcade Video game | Sega Golf Club - Network Pro Tour | 2005 | SEGA Corp. |
| Pachinko | Seibu Keisatsu II | 2005 | Newgin Japan |
| Pachinko | Senda Mitsuo no Honji Tsuna Hana Hadai Kaiten | 2005 | Newgin Japan |
| Sega NAOMI GD-ROM | Senko no Ronde Model GDL-0030 | 2005 | G.Rev |
| Nintendo GBA cart. | Sennen Kazoku Model AGB-BKAJ-JPN | 2005 | Nintendo Co., Ltd. Japan |
| PC/MS-Windows CD | Serious Sam II | 2005 | 2K Games, Inc. New York, NY, USA |
| Adobe Flash game | Sesame Street - Alphabet Soup | 2005 | Sesame Workshop |
| Pachinko | Sevens Rock | 2005 | Sansei R&D Japan |
| Sony PlayStation 2 disc | Shadow of Rome Model SLES-52950 | 2005 | Capcom Co., Ltd. Japan |
| Sony PlayStation 2 disc |  Shadow of Rome Model SLPM-65883 | 2005 | Capcom Co., Ltd. Japan |
| Sony PlayStation 2 disc | Shadow of Rome Model SLUS-20902 | 2005 | Capcom Ent., Inc. USA 13388 |
| Nintendo GameCube disc | Shadow the Hedgehog | 2005 | SEGA of America, Inc. San Francisco, CA, USA |
| Nintendo GameCube disc | Shadow the Hedgehog | 2005 | SEGA Corp. |
| Nintendo GameCube disc | Shadow the Hedgehog Model DOL-GUPP-EUR | 2005 | SEGA Europe Ltd. |
| Slot Machine | Shake Your Booty Bingo | 2005 | IGT International Game Technologies Reno, NV, USA |
| Nintendo GBA cart. | Shamu's Deep Sea Adventures Model AGB-BBAE-USA | 2005 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows CD | Shattered Union | 2005 | 2K Games, Inc. New York, NY, USA |
| Slot Machine | Shijin Retsuden | 2005 | Augus Co., Ltd. Japan |
| Pachinko | Shiki Ranman | 2005 | Newgin Japan |
| Arcade Video game | Shikigami no Shiro III | 2005 | Alfa System |
| Nintendo GBA cart. | Shin Bokura no Taiyou - Gyakushuu no Sabata Model AGB-U33J-JPN | 2005 | Konami Corp. Japan |
| Nintendo GBA cart. | Shin Chan - Aventuras en Cineland Model AGB-BKCS-ESP | 2005 | Atari Interactive, Inc. |
| Pachinko | Shin Daiku no Gen-san | 2005 | Sanyo Japan |
