| Sinclair ZX Spectrum cass. |  Run Bill Run Hb | 2005 | CEZ Games Studio Computer EmuZone |
| Sony PlayStation 2 disc |  Ryu ga Gotoku Taikenban Model SLPM-61140 | 2005 | SEGA Corp. |
| Sony PlayStation 2 disc | Ryu ga Gotoku Model SLPM-66168 | 2005 | SEGA Corp. |
| Pachinko | Ryuoh Densetsu 2 | 2005 | Toyomaru Japan |
| PC/MS-Windows CD | Sacred Underground | 2005 | Take-Two Interactive |
| Medal video game | Saika Ranman Galaxy World Series | 2005 | Konami Digital Ent. Co., Ltd. |
| MSX cart. | Saimazoom Hb | 2005 | Karoshi Corp. |
| Sony PlayStation 2 disc | Saint Seiya - Sanctuary Juunikyuu-hen Model SLPS-25476 | 2005 | Bandai Co., Ltd. Japan |
| Sony PlayStation 2 disc |  Saint Seiya - The Sanctuary Model SLES-53201 | 2005 | Bandai Co., Ltd. Japan |
| Pachislot | Sakura Taisen | 2005 | Eleco, Ltd. Aruze Group Japan |
| PC/MS-Windows CD | Sakura Taisen 4 | 2005 | SEGA Corp. |
| Pachislot | Sakura Taisen Yozakura ver. | 2005 | Eleco, Ltd. Aruze Group Japan |
| Slot Machine | Sally | 2005 | Bally Wulff |
| Pachinko | Samahzukayo! | 2005 | AAA Ace Active Amusement Japan |
| Mattel Intellivision cart. | SameGame & Robots Model 9114 | 2005 | IntelligentVision |
| Arcade Video game | Samurai Shodown VI | 2005 | SNK Playmore Japan |
| Sammy Atomiswave cart. | Samurai Spirits - Tenkaichi Kenkakuden | 2005 | SNK Playmore Japan |
| Sony PlayStation 2 disc | Samurai Warriors - Xtreme Legends Model SLES-53002 | 2005 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Samurai Warriors - Xtreme Legends Model SLES-53003 | 2005 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Samurai Warriors - Xtreme Legends Model SLES-53004 | 2005 | KOEI Co., Ltd. Japan |
| Nintendo GBA cart. | Sangokushi - Eiketsuden Model AGB-B3EJ-JPN | 2005 | KOEI Co., Ltd. Japan |
| Nintendo GBA cart. | Sangokushi Koumeiden Model AGB-B3QJ-JPN | 2005 | KOEI Co., Ltd. Japan |
| Sony PlayStation 2 disc | Sanyo Pachinko Paradise 11 Model SLPS-25455 | 2005 | Irem Soft. Engineering, Inc. Japan |
| Medal video game | Sapphire Gold | 2005 | Sapphire Electronics Co. Korea |
| Sony PSP UMD | Saru Get You P! | 2005 | Sony Computer Ent., Inc. SCEI Japan |
| Sony PlayStation CD |  Saru! Get You! Model SCPS-91331 | 2005 | Sony Computer Ent., Inc. SCEI Japan |
| Pachislot | SaruKani 711 | 2005 | Bellco Corp. Japan |
| Pachinko | Savanna King | 2005 | Heiwa Japan |
| Slot Machine | Say Cheese | 2005 | WMS Gaming, Inc. Chicago, IL, USA |
| PC/MS-Windows CD | SCAR - Squadra Corse Alfa Romeo | 2005 | Black Bean Games |
| Sony PlayStation CD | Schnappi - 3 Fun-Games Model SLES-04177 | 2005 | Phenomedia Publishing GmbH |
| LeapFrog Leapster cart. | Scholastic - Animal Genius | 2005 | LeapFrog |
| LeapFrog Leapster cart. | Scholastic - Math Missions | 2005 | LeapFrog |
| LeapFrog Leapster cart. | Scholastic I Spy - Challenger | 2005 | LeapFrog |
| Nintendo GBA cart. | Scooby-Doo Unmasked Model AGB-B25E-USA | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo GBA cart. | Scooby-Doo Unmasked Model AGB-B25P | 2005 | T-HQ, Inc. Toy HeadQuarters |
| Dedicated Console | Scooby-Doo! and the Mystery of the Castle | 2005 | Jakks Pacific, Inc. |
| VTECH V.Smile cart. | Scooby-Doo! Griezelen in het Pretpark | 2005 | VTECH Video Technology, Ltd. |
| Fisher-Price I Can Play Piano cart. | Scooby-Doo! Monster Mayhem Model J7525 | 2005 | Fisher-Price |
| LeapFrog Leapster cart. | Scooby-Doo! Spooky Snacks! | 2005 | LeapFrog |
