| PC/MS-Windows CD |  Emergency Fire Response | 2003 | DreamCatcher Interactive |
| PC/MS-Windows CD | Empires - Dawn of the Modern World | 2003 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Slot Machine | Enchanted Fortunes | 2003 | WMS Gaming, Inc. Chicago, IL, USA |
| Slot Machine | Enjoy Wild | 2003 | Subsino Co., Ltd. |
| Takara e-Kara EC series cart. | Enka Taizen Dai San-hen Model EC0085-ETZ | 2003 | Takara Co., Ltd. Japan |
| PC/MS-Windows CD | Enter the Matrix | 2003 | Atari Interactive, Inc. |
| Nintendo GameCube disc | Enter the Matrix Model DOL-GMXE-USA | 2003 | Atari, Inc. NY, USA |
| Nintendo GameCube disc | Enter the Matrix Model DOL-GMXP-EUR | 2003 | Atari Europe S.A.S.U. |
| Sony PlayStation CD | Equestriad 2001 Model SLES-02943 | 2003 | Midas Int. Ent. |
| Sony PlayStation CD |  Equestrian Showcase Model SLUS-01462 | 2003 | Mud Duck Productions |
| Slot Machine | ER Fever | 2003 | Konami Gaming, Inc. Las Vegas, NV, USA |
| Sega Dreamcast GD | Erde - Nezu no Ki no Shita de Model T-19720M | 2003 | KID Kindle Imagine Develop |
| Arcade Video game | Espgaluda | 2003 | Cave Co., Ltd. Japan |
| Sony PlayStation 2 disc | ESPN NHL Hockey Model SLES-51948 | 2003 | SEGA Corp. |
| PC/MS-Windows CD | Etherlords II | 2003 | Strategy First |
| GamePark GP32 cart. | Eunhaengnamu Sonyeo Mil | 2003 | GamePark |
| PC/MS-Windows CD | Euratchacha Mu Daeri P | 2003 | Wizard Soft Korea |
| Slot Machine | Eureka Gold Mine | 2003 | Stargames, Ltd. Australia |
| Sony PlayStation 2 disc | EVE - Burst Error Plus Model SLPM-65320 | 2003 | C's Ware |
| Sony PlayStation CD |  EVE - The Lost One Model SLPM-87246~8 | 2003 | Gamevillage |
| PC/MS-Windows CD | EverQuest - Lost Dungeons Of Norrath | 2003 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | EverQuest - The Legacy of Ykesha | 2003 | Sony Online Ent., Inc. |
| Redemption mechanical game | Everyone Wins Junior | 2003 | WGA Win n Grin Amusements Australia |
| Tomy Evio cart. | Evio Challenge! Model eM18 | 2003 | Tomy |
| Tomy Evio cart. | Evio Selection 01 Model eM1 | 2003 | Tomy |
| Tomy Evio cart. | Evio Selection 02 Model eM2 | 2003 | Tomy |
| Tomy Evio cart. | Evio Selection 03 Model eM9 | 2003 | Tomy |
| Tomy Evio cart. | Evio Selection 04 Model eM15 | 2003 | Tomy |
| Dedicated Console | Excite Fishing DX | 2003 | Epoch Co., Ltd. Tokyo, Japan |
| Arcade Video game | Extra Draw | 2003 | IGS Co., Ltd. International Game System |
| Pachislot | Extra Seven | 2003 | Okazaki Sangyo Co., Ltd. Japan |
| Sony PlayStation CD | Extreme Go-Kart Racing Model SLUS-01530 | 2003 | A1 Games |
| Nintendo GBA cart. | Extreme Skate Adventure Model AGB-BESE-USA | 2003 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Nintendo GBA cart. | Extreme Skate Adventure Model AGB-BESP | 2003 | Activision Publishing, Inc. Los Angeles, CA, USA 47875 |
| Slot Machine | Exxxtra Special Effects | 2003 | IGT International Game Technologies Reno, NV, USA |
| Arcade Video game | ExZeus | 2003 | Tsunami Visual Technologies |
| Arcade Video game | Ez2dancer UK Move Special Edition | 2003 | Amuse World Corp. Seoul, Korea |
| Arcade Video game | Ez2DJ Dual Platinum | 2003 | Amuse World Corp. Seoul, Korea |
| Arcade Video game | Ez2DJ Mini | 2003 | Amuse World Corp. Seoul, Korea |
| Arcade Video game | Ez2DJ Platinum: Limited Edition | 2003 | Amuse World Corp. Seoul, Korea |
