| Takara e-Kara US series cart. |  e-kara US Vol. 6 Model US-E006 | 2001 | Takara Co., Ltd. Japan |
| PC/MS-Windows CD | E-Racer | 2001 | KOCH Media Deutschland GmbH |
| Sega Dreamcast GD | E.O.S. - Exhibition of Speed Model T-22903D-50 | 2001 | Titus Gagny, France |
| Nintendo GBA cart. | E.T. - The Extra-Terrestrial | 2001 | UBI Soft Creteil, France 307211 |
| Nintendo GBA cart. | E.T. - The Extra-Terrestrial Model AGB-AETE-USA | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Digital Companion Model CGB-BETE-USA | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Escape from Planet Earth Model CGB-BERE-USA | 2001 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | E.T. The Extra Terrestrial - Escape from Planet Earth Model CGB-BERP-EUR | 2001 | NewKidCo International, Inc. |
| Sony PlayStation CD | E.T. the Extra-Terrestrial - Interplanetary Mission Model SLUS-01385 | 2001 | NewKidCo International, Inc. |
| Sony PlayStation CD |  EA Sports Supercross Model SLES-03399 | 2001 | EA Sports |
| Nintendo GBA cart. | Earthworm Jim Model AGB-AEJE-USA | 2001 | Majesco Sales, Inc. |
| Nintendo GBA cart. | Earthworm Jim Model AGB-AEJP | 2001 | Majesco Sales, Inc. |
| Redemption mechanical game | Easy Go | 2001 | Unknown Korea |
| Sega Dreamcast GD |  Ecco II - Sentinels of the Universe | 2001 | SEGA Corp. |
| Sega Dreamcast GD | Ecco the Dolphin - Defender of the Future Model HDR-0103 | 2001 | SEGA Corp. |
| Nintendo GBA cart. | Ecks vs Sever Model AGB-AESE-USA | 2001 | BAM! Ent. |
| Nintendo GBA cart. | Ecks vs Sever Model AGB-AESP | 2001 | BAM! Ent. |
| Pachislot | Eco To-Fu | 2001 | Net Corp. Japan |
| Sega Dreamcast GD | ECW Anarchy Rulz Model T-8119D-50 | 2001 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Pachislot | Edo1Ban | 2001 | Taiyo Co., Ltd. Japan |
| Sony PlayStation CD | Egipto II - La Profecia de Heliopolis Model SLES-03491 | 2001 | Cryo Interactive Ent. |
| Sony PlayStation CD | Egypt II - Die Prophezeiung von Helipolis Model SLES-03374 | 2001 | Cryo Interactive Ent. |
| Sony PlayStation CD | Egypt II - La Profezia di Heliopolis Model SLES-03490 | 2001 | Cryo Interactive Ent. |
| Sony PlayStation CD | Egypt II - La Prophetie d'Heliopolis Model SLES-03372 | 2001 | Cryo Interactive Ent. |
| Sony PlayStation CD | Egypt II - The Heliopolis Prophecy Model SLES-03373 | 2001 | Cryo Interactive Ent. |
| Sony PlayStation CD | Eithea Model SLPS-03058~9 | 2001 | Atlus Co., Ltd. Japan |
| Sony PlayStation CD | Eithea Model SLPS-03141~2 | 2001 | Atlus Co., Ltd. Japan |
| Bingo | El Dorado | 2001 | Sirmo Belgium |
| Sega Dreamcast GD | Eldorado Gate Dai-3-kan Model T-1225M | 2001 | Capcom Co., Ltd. Japan |
| Sega Dreamcast GD | Eldorado Gate Dai-4-kan Model T-1226M | 2001 | Capcom Co., Ltd. Japan |
| Sega Dreamcast GD | Eldorado Gate Dai-5-kan Model T-1227M | 2001 | Capcom Co., Ltd. Japan |
| Sega Dreamcast GD | Eldorado Gate Dai-6-kan Model T-1228M | 2001 | Capcom Co., Ltd. Japan |
| Sega Dreamcast GD | Eldorado Gate Dai-7-kan Model T-1229M | 2001 | Capcom Co., Ltd. Japan |
| Arcade Video game | Electraride: Ultimate Race Pro | 2001 | Kalisto Ent. |
| Acorn Electron 3.5in. disk | Electron User Group #56 | 2001 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #56 | 2001 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #57 | 2001 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #57 | 2001 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #58 | 2001 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #58 | 2001 | EUG Electron User Group |
