| Nintendo Game Boy Color cart. |  Croc 2 Model CGB-BK2E-USA | 2001 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo Game Boy Color cart. |  Croc 2 Model CGB-BK2P-EUR | 2001 | T-HQ, Inc. Toy HeadQuarters |
| Slot Machine | Crocodile Cash | 2001 | WMS Gaming, Inc. Chicago, IL, USA |
| Nintendo Game Boy Color cart. | Cross Hunter - Monster Hunter Model CGB-BC8J-JPN | 2001 | NetVillage Japan |
| Nintendo Game Boy Color cart. | Cross Hunter - Treasure HunterModel CGB-BC7J-JPN | 2001 | NetVillage Japan |
| Nintendo Game Boy Color cart. | Cross Hunter - X Hunter Model CGB-BC9J-JPN | 2001 | NetVillage Japan |
| Fruit Machine | Crossfire | 2001 | JPM International |
| PC/MS-Windows CD | CrossGate | 2001 | Square Enix Co., Ltd. Japan |
| Sony PlayStation CD | Crossroad Crisis Model SLUS-01342 | 2001 | A1 Games |
| Nintendo GBA cart. | Crouching Tiger, Hidden Dragon Model AGB-AQDE-USA | 2001 | UBI Soft Ent., Inc. San Francisco, CA, USA 08888 |
| Nintendo GBA cart. | Crouching Tiger, Hidden Dragon Model AGB-AQDP | 2001 | UBI Soft Creteil, France 307211 |
| Nintendo GBA cart. | Cruis'n Velocity Model AGB-ACFE-USA | 2001 | Midway Home Ent. |
| Nintendo GBA cart. | Cruis'n Velocity Model AGB-ACFP | 2001 | Midway Home Ent. |
| Atari 400/800 cart. | Crystal Raiders | 2001 | Video 61 |
| Slot Machine | Crystal Sevens 2-Coin | 2001 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Crystal Sevens 3-Coin | 2001 | IGT International Game Technologies Reno, NV, USA |
| Slot Machine | Crystal Sevens 5-Coin | 2001 | IGT International Game Technologies Reno, NV, USA |
| Nintendo Game Boy Color cart. | Cubix - Robots for Everyone - Race 'n Robots Model CGB-BCXE-USA | 2001 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Cubix Robots for Everyone - Race 'n Robots Model SLUS-01422 | 2001 | 3DO Co., The CA, USA |
| Sega Dreamcast GD | Culdcept II Model T-43903M | 2001 | Media Factory Japan |
| PC/MS-Windows CD | Cultures | 2001 | T-HQ, Inc. Toy HeadQuarters |
| Commodore C64 disk | CWS Boulder Dash Hb | 2001 | CWS |
| Pachislot | Cyber Dragon | 2001 | Yamasa Japan |
| Arcade Video game | Cyber Troopers Virtual-On 4 'Force' | 2001 | SEGA Corp. |
| PDA |  Cybiko Xtreme | 2001 | Cybiko, Inc. |
| Sony PlayStation CD |  Cyclone Best: Assault Suits Valken 2 Model SLPM-86872 | 2001 | Four Winds |
| Sony PlayStation CD | Cyclone Best: Burger Burger Model SLPM-86853 | 2001 | Four Winds |
| Sony PlayStation CD | Cyclone Best: DonPachi Model SLPS-86855 | 2001 | SPS Japan |
| Sony PlayStation CD | Cyclone Best: Maria 2 - Jutai Kokuchi no Nazo Model SLPM-86850~2 | 2001 | Axela |
| Sega Dreamcast GD | D+Vine (Luv) Model T-46501M | 2001 | Princess Soft |
| Sega Dreamcast GD | D+Vine (Luv) Model T-46502M | 2001 | Princess Soft |
| PC/MS-Windows CD | D.i.G | 2001 | Aaru Japan |
| Nintendo GBA cart. | Dai-mahjong. Model AGB-AHMJ-JPN | 2001 | Hori |
| PC/MS-Windows CD | Daiakuji | 2001 | Alicesoft Japan |
| Nintendo Game Boy Color cart. | Daikatana GB Model CGB-A22J-JPN | 2001 | Kemco, Ltd. |
| Nintendo GameCube disc | Dairantou Smash Brothers DX Model DOL-GALJ-JPN | 2001 | Nintendo Co., Ltd. Japan |
| Nintendo GBA cart. | Daisenryaku for Game Boy Advance Model AGB-ADSJ-JPN | 2001 | MediaKite Japan |
| Sony PlayStation CD | Dance Dance Revolution - 4th Mix Model SLPM-86752 | 2001 | Konami Corp. Japan |
| Sony PlayStation CD | Dance Dance Revolution - 5th Mix Model SLPM-86897 | 2001 | Konami Corp. Japan |
| Sony PlayStation CD | Dance Dance Revolution - Disney Mix Model SLUS-01281 | 2001 | Konami of America CA, USA |
