| Sony PlayStation CD |  Artdink Best Choice: Neo Atlas II Model SLPS-02974 | 2000 | Artdink Corp. Japan |
| Sony PlayStation CD | Artdink Best Choice: The Conveni Special - 3-tsu no Sekai o Dokusen Seyo Model SLPS-02539 | 2000 | Artdink Corp. Japan |
| Sony PlayStation CD | Artdink Best Choice: The Famires Model SLPS-02538 | 2000 | Artdink Corp. Japan |
| Sony PlayStation CD |  Arthur! Ready to Race Model SLUS-01090 | 2000 | Learning Co., The |
| Nintendo Game Boy Color cart. | Arthur's Absolutely Fun Day! Model CGB-BFDE-USA | 2000 | Learning Co., The |
| PC/MS-Windows CD | Arthur's Knights - Tales of Chivalry | 2000 | DreamCatcher Interactive |
| Takara e-Kara EC series cart. | Artist Selection Vol. 1 Model EC0014-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 2 Model EC0015-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 3 Model EC0029-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 4 Model EC0031-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 5 Model EC0035-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 6 Model EC0036-ATS | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | Artist Selection Vol. 7 {Model EC0039-ATS | 2000 | Takara Co., Ltd. Japan |
| Sony PlayStation CD | ASCII Casual Collection: End Sector Model SLPS-02972 | 2000 | ASCII Corp. Japan |
| Sony PlayStation CD | ASCII Casual Collection: Mahjong Ganryuujima Model SLPS-02979 | 2000 | ASCII Corp. Japan |
| Sony PlayStation CD | ASCII Casual Collection: Nijiiro Twinkle - Guru Guru Daisakusen Model SLPS-01506 | 2000 | ASCII Corp. Japan |
| Thomson TO disk | AsmExt | 2000 | Prehis-To |
| Pachinko | Asonde China | 2000 | Sanyo Japan |
| Sony PlayStation CD |  Asterix & Obelix contro Cesare Model SLES-02474 | 2000 | Cryo Interactive Ent. |
| Sony PlayStation CD | Asterix & Obelix Take On Caesar Model SLES-02092 | 2000 | Cryo Interactive Ent. |
| Sony PlayStation CD | Asterix & Obelix Take On Caesar Model SLES-02473 | 2000 | Cryo Interactive Ent. |
| Sony PlayStation CD | Asterix & Obelix Take On Caesar Model SLES-02475 | 2000 | Cryo Interactive Ent. |
| Apple Macintosh disk | Asteroids | 2000 | Infogrames Interactive, Inc. 329720 |
| Nintendo Game Boy Color cart. | Astérix - Search for Dogmatix Model CGB-AA6P-ESP | 2000 | Infogrames Europe 546430 |
| Arcade Video game | Asura Buster - Eternal Warriors | 2000 | Fuuki Co., Ltd. Kyoto, Japan |
| PC/MS-Windows CD | Atari Arcade Hits 2 | 2000 | Hasbro Interactive, Inc. |
| Pachislot | Athanasia | 2000 | Baltec Japan |
| Pachislot | Atlantis Doom | 2000 | Heiwa Japan |
| PC/MS-Windows CD | Atrox | 2000 | OK Interactive Korea |
| Sega Dreamcast GD | Atsumare! Guru Guru Onsen BB Model HDR-0121 | 2000 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Atsumare! Guru Guru Onsen Web Money Card Ver. Model HDR-0120 | 2000 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Nintendo Game Boy Color cart. | Atsumete Asobu Kuma no Pooh-san - Mori no Takaramono Model CGB-BPUJ-JPN | 2000 | Tomy |
| PC/MS-Windows CD | Attack of the Saucerman | 2000 | Psygnosis, Ltd. |
| Sony PlayStation CD | ATV - Quad Power Racing Model SLES-02822 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ATV - Quad Power Racing Model SLPM-86636 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ATV - Quad Power Racing Model SLUS-01137 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | Aura Battler Dunbine - Seisenshi Densetsu Model SLPS-02390 | 2000 | Bandai Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Austin Powers - Oh, Behave! Model CGB-BAPE-USA | 2000 | Rockstar Games |
| Nintendo Game Boy Color cart. | Austin Powers - Oh, Behave! Model CGB-BAPX-UKV | 2000 | Rockstar Games |
| Nintendo Game Boy Color cart. | Austin Powers - Welcome to my Underground Lair! Model CGB-BEAE-USA | 2000 | Rockstar Games |
