| Arcade Video game |  Florida Skill Deluxe 2000 | 2000 | Unknown |
| PC/MS-Windows CD | Fly 2K | 2000 | Take-Two Interactive |
| PC/MS-Windows CD | Flying Heroes | 2000 | Take-Two Interactive |
| Konami System 573 disc+cart. | Football Masters | 2000 | Konami Corp. Japan |
| Sony PlayStation CD | Football Midseason Update for Madden NFL 2001 Model G-22810 | 2000 | InterAct Accessories, Inc. |
| Nintendo Game Boy Color cart. | Force 21 Model CGB-BFCE-USA | 2000 | Red Storm Ent. |
| Sony PlayStation CD |  Ford Racing Model SLUS-01301 | 2000 | Empire Interactive Europe, Ltd. |
| PC/MS-Windows CD | Forgotten Realms: Baldur's Gate II - Shadows of Amn | 2000 | Interplay |
| PC/MS-Windows CD | Forgotten Realms: Icewind Dale | 2000 | Interplay |
| Sony PlayStation CD | Formula Nippon Model SLES-02526 | 2000 | Eon Digital Ent. |
| Sony PlayStation CD | Formula Nippon Model SLES-02527 | 2000 | Eon Digital Ent. |
| Nintendo Game Boy Color cart. | Formula One 2000 Model CGB-BFME-USA | 2000 | Take-Two Interactive |
| Sony PlayStation CD | Formula One 2000 Model SCES-02777 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Formula One 2000 Model SCES-02778 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Formula One 2000 Model SCES-02779 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Formula One 2000 Model SLUS-01134 | 2000 | Sony Computer Ent. America SCEA CA, USA |
| PC/MS-Windows CD | Fort Boyard - Millenium | 2000 | Microïds |
| Commodore Amiga CD | Foundation - The Undiscovered Land | 2000 | Epic Marketing |
| Slot Machine | Four Play Blackjack | 2000 | IGT International Game Technologies Reno, NV, USA |
| IBM PC/AT DOS pack. | FoX | 2000 | Gardiner & McAuley |
| PC/MS-Windows CD | Fox Sci-Fi Pinball | 2000 | Fox Interactive |
| Sony PlayStation CD | FoxKids.com: Micro Maniacs Racing Model SLUS-01129 | 2000 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Visual Memory Unit mini-game | Freak Skater 2 Hb | 2000 | Freakware |
| PC/MS-Windows CD | Freedom - First Resistance | 2000 | UBI Soft Creteil, France 307211 |
| Samsung Nuon disc | FreeFall 3050 A.D. | 2000 | VM Labs, Inc. |
| Sony PlayStation CD | Freestyle Motocross - McGrath vs. Pastrana Model SLES-02820 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | Freestyle Motocross - McGrath vs. Pastrana Model SLUS-01122 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Phillips CD-i disc | Frog Feast | 2000 | Rastersoft |
| PC/MS-Windows CD | Frogger 2 - Swampy's Revenge | 2000 | Hasbro Interactive, Inc. |
| Sony PlayStation CD | Frogger 2 - Swampy's Revenge Model SLES-02853 | 2000 | Hasbro Interactive, Inc. |
| Sony PlayStation CD | Frogger 2 - Swampy's Revenge Model SLUS-01172 | 2000 | Hasbro Interactive, Inc. |
| Sega Dreamcast GD | Frogger 2 - Swampy's Revenge Model T-40604N | 2000 | Hasbro Interactive, Inc. |
| Nintendo Game Boy Color cart. | Frogger 2 Model CGB-BH2E-USA | 2000 | Majesco Sales, Inc. |
| Bandai WonderSwan cart. | From TV Animation One Piece - Mezase Kaizoku Ou! Model SWJ-BAN02B | 2000 | Bandai Co., Ltd. Japan |
| Sony PlayStation CD | Front Mission 3 Model SLES-02423 | 2000 | Square Co., Ltd. Japan |
| Sony PlayStation CD | Front Mission 3 Model SLUS-01011 | 2000 | Square Electronic Arts L.L.C. |
| Sony PlayStation CD | Frontschweine Model SLES-02767 | 2000 | Infogrames Europe 546430 |
| Video Slot Machine | Fruit Bonus 2000 - New Cherry 2000 | 2000 | Amcoe, Inc. USA |
| Sony PlayStation CD | Fukyuuban 1500 Series: Kowloon-jou Model SLPS-03063 | 2000 | Media Rings Corp. Japan |
| Sony PlayStation CD |  Fukyuuban 1500 Series: Saibara Rieko no Mahjong Toriatama Kikou Model SLPS-03064 | 2000 | Media Rings Corp. Japan |
