| Acorn Electron 3.5in. disk |  Electron User Group #54 | 2000 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #54 | 2000 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #55 | 2000 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #55 | 2000 | EUG Electron User Group |
| Nintendo Game Boy Color cart. | Elemental Tale - Jack no Daibouken - Daimaou no Gyakushuu Model DMG-AQJJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Slot Machine | Elephant King | 2000 | IGT International Game Technologies Reno, NV, USA |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXJ-JPN | 2000 | Altron Corp. |
| Nintendo Game Boy Color cart. | Elevator Action EX Model CGB-BEXP-EUR | 2000 | TDK Recording Media Europe S.A. |
| PC/MS-Windows CD | Elf All Star Datsui-Jan | 2000 | Elf Japan |
| Nintendo Game Boy Color cart. | Elie no Atelier GB Model DMG-A8EJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| PC/MS-Windows CD | Emergency Police | 2000 | KOCH Media Deutschland GmbH |
| PC/MS-Windows CD | Empire of the Ants | 2000 | Microïds |
| Sony PlayStation CD |  En Busca del Valle Encantado - El Retorno al Gran Valle Model SLES-02985 | 2000 | TDK Recording Media Europe S.A. |
| Video Slot Machine | Enchanted Forest Cash Express | 2000 | Aristocrat Leisure Industries Pty, Ltd. |
| Pachinko | Engi Man | 2000 | Heiwa Japan |
| Takara e-Kara EC series cart. | ENK Vol. 1 Model EC0006-ENK | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | ENK Vol. 2 Model EC0016-ENK | 2000 | Takara Co., Ltd. Japan |
| Takara e-Kara EC series cart. | ENK Vol. 3 Model EC0030-ENK | 2000 | Takara Co., Ltd. Japan |
| PC/MS-Windows CD | Escape from Monkey Island | 2000 | LucasArts Ent. Co. |
| Sony PlayStation 2 disc | ESPN International Track & Field 2000 Model SLES-50036 | 2000 | Konami Corp. Japan |
| Nintendo Game Boy Color cart. | ESPN International Track & Field Model CGB-B3HE-USA | 2000 | Konami Co., Ltd. Japan |
| Sega Dreamcast GD | ESPN International Track & Field Model T-9504D-76 | 2000 | Konami Corp. Japan |
| Sega Dreamcast GD | ESPN International Track & Field Model T-9509N | 2000 | Konami Corp. Japan |
| Sony PlayStation CD | ESPN MLS Gamenight Model SLUS-01186 | 2000 | Konami of America CA, USA |
| Sega Dreamcast GD | ESPN NBA 2Night Model T-9503N | 2000 | Konami Corp. Japan |
| Sony PlayStation CD |  Esto Es Futbol 2 demo Model SCED-03205 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Esto Es Futbol 2 Model SCES-03076 | 2000 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Eternal Eyes Model SLES-02270 | 2000 | SUNSOFT Kounan, Japan |
| Sony PlayStation CD | Eternal Eyes Model SLUS-01034 | 2000 | Crave Ent., Inc. |
| PC/MS-Windows CD | Euro 2000 | 2000 | Electronic Arts CA, USA 14633 |
| PC/MS-Windows CD | Europa Universalis - Crown of the North | 2000 | Paradox Interactive |
| PC/MS-Windows CD | EVE - Burst Error | 2000 | Himeya Soft., Inc. Japan |
| Sony PlayStation CD | Eve Zero Model SLPM-86478~80 | 2000 | NetVillage Japan |
| PC/MS-Windows CD | EverQuest - The Ruins of Kunark | 2000 | Sony Online Ent., Inc. |
| PC/MS-Windows CD | EverQuest - The Scars of Velious | 2000 | Sony Online Ent., Inc. |
| Sony PlayStation CD | Everybody's Golf 2 Model SCES-02146 | 2000 | Sony Computer Ent., Inc. SCEI Japan |
| Sony PlayStation CD | Evil Dead - Hail to the King Model SLUS-01072/01326 | 2000 | T-HQ, Inc. Toy HeadQuarters |
| Sega Dreamcast GD | Evil Dead - Hail to the King Model T-10003N | 2000 | T-HQ, Inc. Toy HeadQuarters |
| PC/MS-Windows CD | Evil Force - Mirror War | 2000 | E2 Soft Korea |
| Sony PlayStation CD | Evo's Space Adventures Model SLES-01871 | 2000 | Take-Two Interactive |
