| Sony PlayStation 2 disc |  Driving Emotion Type-S Model SLPS-20007 | 2000 | Square Co., Ltd. Japan |
| PC/MS-Windows CD | Droiyan 2 - Absolute Monarch | 2000 | E2 Soft Korea |
| Arcade Video game | Drum Star | 2000 | Koreal Info Net Co., Ltd. |
| Konami System 573 disc+cart. | DrumMania 2ndMix Model GQ881 | 2000 | Konami Co., Ltd. Japan |
| Konami System 573 disc+cart. | DrumMania 3rdMix Model GCA23 | 2000 | Konami Corp. Japan |
| Coin-op Misc. game | Drumscape - Drum Challenge | 2000 | Devecka Enterprises, Inc. Morris Township, NJ, USA |
| Nintendo Game Boy Color cart. | Drymouth | 2000 | Demiforce |
| PC/MS-Windows CD | DT Racing - Sprint Cars | 2000 | Take-Two Interactive |
| Nintendo 64 cart. | Duck Dodgers Starring Daffy Duck | 2000 | Infogrames Interactive, Inc. 329720 |
| Pachislot | Duel Dragon | 2000 | Universal Co., Ltd Tokyo, Japan |
| Sony PlayStation CD | Duke Nukem - Land of the Babes Model SLUS-01002 | 2000 | GT Interactive Soft. Corp. NY, USA |
| PC/MS-Windows CD | Dukes of Hazzard | 2000 | UBI Soft Creteil, France 307211 |
| PC/MS-Windows CD |  Dungeon Keeper 3 - War for the Overworld | 2000 | Bullfrog Productions, Ltd. An Electronic Arts co. |
| Atari ST disk | Dungeon Master Data Disk 4 - Bennis Dungeon 1 - The Lair of Chaos | 2000 | FTL Faster Than Light |
| Nintendo Game Boy Color cart. | Dungeon Savior Model DMG-ADWJ-JPN | 2000 | J-Wing |
| Nichibutsu High Rate DVD | DVD Select 18 | 2000 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Nintendo Game Boy Color cart. | DX Monopoly GB Model DMG-BMPJ-JPN | 2000 | Takara Co., Ltd. Japan |
| Sony PlayStation CD | DX Monopoly Model SLPS-02943 | 2000 | Takara Co., Ltd. Japan |
| Arcade Video game | Dynamite Bomber | 2000 | Limenko, Ltd. Seoul, Korea |
| Pachislot | Dynamite Kid's | 2000 | Matsuya |
| SNK Neo-Geo Pocket Color cart. | Dynamite Slugger Model NEOP00710 | 2000 | SNK Corp. Shin Nihon Kikaku Japan |
| Sony PlayStation CD | Dynamite Soccer 2000 Model SLPS-02554 | 2000 | A-Max Japan |
| Sony PlayStation 2 disc |  Dynasty Warriors 2 Model SLUS-20079 | 2000 | KOEI Corp. CA, USA |
| Pachislot | E-Cup | 2000 | Eleco, Ltd. Aruze Group Japan |
| Takara e-Kara US series cart. | e-kara US 5-Songs Starter Model US-M001 | 2000 | Takara Co., Ltd. Japan |
| IBM PC/AT DOS CD |  EA Classics: Dungeon Keeper + Magic Carpet 2 | 2000 | Electronic Arts CA, USA 14633 |
| Sony PlayStation CD | EA Sports Superbike 2000 Model SLES-02538 | 2000 | EA Sports |
| Sony PlayStation CD | EA Sports Superbike 2000 Model SLUS-01052 | 2000 | EA Sports |
| Sony PlayStation CD | EA Sports Supercross Model SLUS-01319 | 2000 | EA Sports |
| Sony PlayStation CD | Eagle One - Harrier Attack Model SLES-01715 | 2000 | Infogrames Europe 546430 |
| Apple II 5.25 disk | Eamon 243: The Dragon of Aldaar Hb | 2000 | Gribble, Glenn |
| PC/MS-Windows CD | Earth 2150 | 2000 | TopWare Interactive AG |
| Fruit Machine | Easy Streak Model PR1017 | 2000 | Bell-Fruit Games Bell-Fruit Group, Ltd. Novomatic Group UK |
| Sega Dreamcast GD | Ecco the Dolphin - Defender of the Future Model 51033 | 2000 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Dreamcast GD | Ecco the Dolphin - Defender of the Future Model MK-51033-50 | 2000 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLES-02823 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLES-03069 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | ECW Anarchy Rulz Model SLUS-01169 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Dreamcast GD | ECW Anarchy Rulz Model T-8114N | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo 64 cart. | ECW Hardcore Revolution | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
