| Sega Dreamcast GD |  Airforce Delta Model 197136 | 2000 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Nintendo Game Boy Color cart. |  AirForce Delta Model CGB-BDLE-USA | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | AirForce Delta Model CGB-BDLJ-JPN | 2000 | Konami Co., Ltd. Japan |
| PC/MS-Windows CD | Airport Tycoon | 2000 | TalonSoft |
| PC/MS-Windows CD | Aishimai | 2000 | Elf Japan |
| Sony PlayStation CD | Aitakute... Your Smiles in My Heart Model SLPM-86254~7 | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Alfred's Adventure Model CGB-BAAP-EUR | 2000 | SCI, Ltd. Sales Curve Interactive |
| Nintendo Game Boy Color cart. | Alice in Wonderland Model CGB-AIWE-USA | 2000 | Nintendo of America, Inc. USA 45496 |
| Nintendo Game Boy Color cart. | Alice in Wonderland Model CGB-AIWP-EUR | 2000 | Nintendo of Europe GmbH 45496 |
| Slot Machine | Alien Panic! | 2000 | Sigma Enterprises, Inc. Tokyo, Japan |
| Sony PlayStation CD | Alien Resurrection Model SLES-02913 | 2000 | Fox Interactive |
| Sony PlayStation CD | Alien Resurrection Model SLUS-00633 | 2000 | Fox Interactive |
| Fruit Machine | All 4 One | 2000 | Vivid Gaming England |
| Slot Machine | All or Nothing Easy Million | 2000 | WMS Gaming, Inc. Chicago, IL, USA |
| Sony PlayStation 2 disc | All Star Pro-Wrestling Model SLPS-20022 | 2000 | Square Co., Ltd. Japan |
| PC/MS-Windows CD | All Star Tennis 2000 | 2000 | UBI Soft Creteil, France 307211 |
| Sony PlayStation CD | All Star Tennis 2000 Model SLES-02764 | 2000 | UBI Soft Creteil, France 307211 |
| Sony PlayStation CD | All Star Tennis Yannick Noah 2000 Model SLES-02765 | 2000 | UBI Soft Creteil, France 307211 |
| Nintendo Game Boy Color cart. | All-Star Baseball 2001 Model CGB-BASE-USA | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo 64 cart. | All-Star Baseball 2001 Model NUS-NASE-USA | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | Alla Ricerca della Valle Incantata - Ritorno alla Grande Vallata Model SLES-02984 | 2000 | TDK Recording Media Europe S.A. |
| PC/MS-Windows CD | Allegiance | 2000 | Microsoft |
| Pachislot | Alot | 2000 | Kitac Kita Denshi Corp. Japan |
| Sony PlayStation CD | Alundra 2 - A New Legend Begins Model SLES-02600 | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sony PlayStation CD | Alundra 2 - A New Legend Begins Model SLUS-01017 | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sony PlayStation CD | Alundra 2 - Der Beginn einer neuen Legende Model SLES-02602 | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Sony PlayStation CD | Alundra 2 - Une Legende est Née Model SLES-02601 | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows CD | Ameiro no Kisetsu | 2000 | ZyX Japan |
| PC/MS-Windows CD | American McGee's Alice | 2000 | Electronic Arts CA, USA 14633 |
| Video Slot Machine | American Poker Five | 2000 | AGI Austrian Gaming Industries Novomatic Group |
| Commodore Amiga CD | Amiga Classix 2 | 2000 | Epic Marketing |
| Commodore Amiga 500 disk | Amiga Format #133 | 2000 | Future Publishing, Ltd. UK |
| Commodore Amiga 500 disk | Amiga Format #134 | 2000 | Future Publishing, Ltd. UK |
| Commodore Amiga 500 disk | Amiga Format #136 | 2000 | Future Publishing, Ltd. UK |
| Commodore Amiga CD | AMIGAplus CD-ROM & Gamer 2000-06 | 2000 | Falke |
| Commodore Amiga CD | Aminet Games | 2000 | Schatztruhe |
| Amstrad CPC 464 disk | Amstrad Technical Magazine V Hb | 2000 | Unknown |
| KidConnection SmarTV Adventures cart. | Amusement Park | 2000 | WinFun |
| HP-39/40 soft. | Android 2 P Hb | 2000 | Pigallio, Lilian |
| Medal video game | Animal Catch | 2000 | Sammy Corp. Japan |
