| Nintendo Game Boy Color cart. |  Dave Mirra Freestyle BMX Model CGB-BMXP-EUR | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD |  Dave Mirra Freestyle BMX Model SLES-02740 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sony PlayStation CD | Dave Mirra Freestyle BMX Model SLUS-01026 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Dreamcast GD | Dave Mirra Freestyle BMX Model T-8120D-50 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Dreamcast GD | Dave Mirra Freestyle BMX Model T-8120N | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Dreamcast GD |  Daytona USA 2001 Taikenban | 2000 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Daytona USA 2001 Model HDR-0106 | 2000 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sony PlayStation CD | De Sang Froid Model SCES-02150/12150 | 2000 | Sony Computer Ent. Europe SCEE |
| Sega Dreamcast GD | Dead or Alive 2 | 2000 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega NAOMI cart. | Dead or Alive 2 Millennium | 2000 | Tecmo, Ltd. Tokyo, Japan |
| Sony PlayStation 2 disc | Dead or Alive 2 Model SLPS-25002 | 2000 | Tecmo, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Dead or Alive 2 Model T-3601M | 2000 | Tecmo, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Dead or Alive 2 Model T-3601N | 2000 | Tecmo, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Dead or Alive 2 Model T-3602M | 2000 | Tecmo, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Dead or Alive 2 Model T-8116D-50 | 2000 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Nintendo Game Boy Color cart. | Deadly Skies Model CGB-BDLP-EUR | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Dear Daniel no Sweet Adventure - Kitty-chan o Sagashite Model DMG-BSAJ-JPN | 2000 | Imagineer Co., Ltd. Japan |
| Sega NAOMI cart. | Death Crimson OX | 2000 | Ecole Soft. |
| PC/MS-Windows CD | Death Track Racing | 2000 | Take-Two Interactive |
| Pachislot | Debut | 2000 | Net Corp. Japan |
| Dedicated Console | Decathlon | 2000 | Advance Bright, Ltd. |
| Sony PlayStation CD | Deception III - Dark Delusion Model SLUS-01067 | 2000 | Tecmo, Inc. CA, USA |
| Pachislot | Deco | 2000 | Vanguard Co., Ltd. |
| PC/MS-Windows CD | Deep Fighter | 2000 | UBI Soft Creteil, France 307211 |
| Sega Dreamcast GD | Deep Fighter Model T-17704D-50 | 2000 | UBI Soft Creteil, France 307211 |
| Sega Dreamcast GD | Deep Fighter Model T-17705N | 2000 | UBI Soft Creteil, France 307211 |
| Slot Machine | Deep Pockets | 2000 | IGT International Game Technologies Reno, NV, USA |
| Arcade Video game | Deer Hunting USA | 2000 | American Sammy Corp. Torrance, CA, USA |
| Nintendo Game Boy Color cart. | Dejiko no Mahjong Party Model CGB-BQSJ-JPN | 2000 | King Records Co., Ltd. Japan |
| Sega Dreamcast GD | Dejiko no Maibura Model T-44601M | 2000 | Isao |
| Pachislot | Dekahel | 2000 | Aruze Corp. Japan |
| Pachislot | Delsol | 2000 | Eleco, Ltd. Aruze Group Japan |
| PC/MS-Windows CD | Delta Force - Land Warrior | 2000 | NovaLogic |
| SNK Neo-Geo Pocket Color cart. | Delta Warp Model NEOP01030 | 2000 | SNK Corp. Shin Nihon Kikaku Japan |
| Arcade Video game | Deluxe 4 U | 2000 | ESD Excellent Soft Design |
| Arcade Video game | Deluxe 5 | 2000 | ESD Excellent Soft Design |
| PC/MS-Windows CD | Demolition Racer | 2000 | Infogrames Interactive, Inc. 329720 |
| Sega Dreamcast GD | Demolition Racer - No Exit Model T-15112N | 2000 | Infogrames Interactive, Inc. 329720 |
| Pachinko | DenDenDen 1Syou | 2000 | Unknown |
| Sony PlayStation CD | Dengeki PlayStation D11: Yarudora Series Vol. 3 Sampaguita Model PAPX-90060 | 2000 | Media Works Japan |
