| Sony PlayStation CD |  Crisis Beat Model SLES-02793 | 2000 | Virgin Interactive Ent., Ltd. UK 013715 |
| PC/MS-Windows CD |  Croc 2 | 2000 | Fox Interactive |
| Nintendo Game Boy Color cart. | Croc Model CGB-BRCE-USA | 2000 | T-HQ, Inc. Toy HeadQuarters |
| Nintendo Game Boy Color cart. | Croc Model CGB-BRCP-EUR | 2000 | T-HQ, Inc. Toy HeadQuarters |
| Bingo | Croce d'oro | 2000 | Splin |
| Nintendo Game Boy Color cart. | Cross Country Racing Model DMG-ARLP-EUR | 2000 | Konami Co., Ltd. Japan |
| Slot Machine | Crown Golden Bell | 2000 | GPS Co., Ltd. Game Power System Taiwan |
| Arcade Video game | Cruis'n Exotica | 2000 | Midway Games, Inc. Chicago, IL, USA |
| Nintendo 64 cart. | Cruis'n Exotica | 2000 | Midway Home Ent. |
| Nintendo Game Boy Color cart. | Cruis'n Exotica Model CGB-BXOE-USA | 2000 | Midway Home Ent. |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLES-02582 | 2000 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLES-02583 | 2000 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLES-02584 | 2000 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLES-02691 | 2000 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLES-02692 | 2000 | 3DO Co., The CA, USA |
| Sony PlayStation CD | Crusaders of Might and Magic Model SLUS-00799 | 2000 | 3DO Co., The CA, USA |
| Nintendo Game Boy Color cart. | Crystalis Model CGB-AYJE-USA | 2000 | Nintendo of America, Inc. USA 45496 |
| Pachislot | Cubby Funk | 2000 | Max Allied |
| Sony PlayStation CD | Culdcept - Expansion Plus Model SLPM-86658 | 2000 | Media Factory Japan |
| Nintendo 64 cart. | Custom Robo V2 Model NUS-NCZJ | 2000 | Nintendo Co., Ltd. Japan |
| Pachislot | Cutie Bomb | 2000 | Eipex Tokyo, Japan |
| Sega Dreamcast GD | Cyber Troopers Virtual On - Oratorio Tangram Model T-13004N | 2000 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Nintendo 64 cart. | CyberTiger | 2000 | Electronic Arts CA, USA 14633 |
| Nintendo Game Boy Color cart. | CyberTiger Model CGB-BCTE-USA | 2000 | Electronic Arts CA, USA 14633 |
| Nintendo Game Boy Color cart. | CyberTiger Model CGB-BCTP-UKV | 2000 | Electronic Arts CA, USA 14633 |
| PDA |  Cybiko Classic | 2000 | Cybiko, Inc. |
| Nintendo Game Boy Color cart. | Cyborg Kuro-chan - Devil Fukkatsu Model CGB-BSKJ-JPN | 2000 | Konami Co., Ltd. Japan |
| Nintendo Game Boy Color cart. | Cyborg Kuro-chan 2 - White Woods no Gyakushuu Model CGB-BSBJ-JPN | 2000 | Konami Co., Ltd. Japan |
| HP-39/40 soft. | Cyclo P Hb | 2000 | Pigallio, Lilian |
| HP-49 soft. | Cyclo P Hb | 2000 | Pigallio, Lilian |
| Redemption mechanical game | Cyclone Fever | 2000 | Konami Corp. Japan |
| Sony PlayStation CD |  D-1 Grand Prix Taikenban Model SLPM-80558 | 2000 | Bandai Co., Ltd. Japan |
| Sega Dreamcast GD | D2 Model 51036 | 2000 | SEGA of America, Inc. San Francisco, CA, USA |
| Nintendo Game Boy Color cart. | Daa! Daa! Daa! Totsuzen Card de Battle de Uranai de! Model CGB-BDOJ-JPN | 2000 | Video System Co., Ltd. Kyoto, Japan |
| Colecovision cart. | DacMan Hb | 2000 | Amy Marie Bienvenu |
| Nintendo Game Boy Color cart. | Daffy Duck - Subette Koron de Taikin Mochi Model DMG-AD7J-JPN | 2000 | SUNSOFT Kounan, Japan |
| Nintendo 64 cart. | Daffy Duck Starring as Duck Dodgers | 2000 | Infogrames Interactive, Inc. 329720 |
| PC/MS-Windows CD | Daikatana | 2000 | Eidos Interactive |
| Nintendo Game Boy Color cart. | Daikatana Model CGB-A22X-EUR | 2000 | Kemco, Ltd. |
| Nintendo Game Boy Color cart. | Daikatana Model CGB-A22Y-EUU | 2000 | Kemco, Ltd. |
