| Sony PlayStation CD |  Essential PlayStation CD Twelve Model SCED-01143 | 1999 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD |  Esto Es Futbol Model SCES-01704 | 1999 | Sony Computer Ent. Europe SCEE |
| Sinclair ZX Spectrum cass. | Eugene Hb | 1999 | Manic Miner Technologies |
| Slot Machine | Eureka! | 1999 | Silicon Gaming, Inc. SGI |
| Sony PlayStation CD | Euro Demo 49 Model SCED-02229 | 1999 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Euro Demo 49 Model SCED-02230 | 1999 | Sony Computer Ent. Europe SCEE |
| Amstrad CPC 464 disk | Euro-WACCI Issue 5 Hb | 1999 | WACCI |
| Amstrad CPC 464 disk | Euro-WACCI Issue 6 Hb | 1999 | WACCI |
| PC/MS-Windows DVD | EVE - Burst Error | 1999 | C's Ware |
| Nintendo Game Boy Color cart. | Evel Knievel Model DMG-AEVE-USA | 1999 | Rockstar Games |
| Nintendo Game Boy Color cart. | Evel Knievel Model DMG-AEVP-EUR | 1999 | Take-Two Interactive |
| PC/MS-Windows CD | EverQuest | 1999 | Sony Online Ent., Inc. |
| Pachislot | Evil Head | 1999 | Taiyo Co., Ltd. Japan |
| Sony PlayStation CD |  Evil Zone Model SLES-01903 | 1999 | Titus Gagny, France |
| Sony PlayStation CD | Evil Zone Model SLUS-00855 | 1999 | Titus Gagny, France |
| Sega Dreamcast GD | Evolution - The World of Sacred Device Model T-17706N | 1999 | UBI Soft Creteil, France 307211 |
| Sony PlayStation CD | Exciting Bass 2 Model SLPM-86295 | 1999 | Konami Co., Ltd. Japan |
| Sony PlayStation CD | Exclusive PlayStation Racing Demos Model SCED-02043 | 1999 | Sony Computer Ent. Europe SCEE |
| Sega Dreamcast GD | Expendable Model T-15104N | 1999 | Infogrames Interactive, Inc. 329720 |
| PC/MS-Windows CD | Expert Pool | 1999 | Psygnosis, Ltd. |
| PC/MS-Windows CD | Extreme Bullrider | 1999 | Activision, Inc. Los Angeles, CA, USA 47875 |
| PC/MS-Windows CD | Extreme G 2 | 1999 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| PC/MS-Windows CD | Extreme Watersports | 1999 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Nintendo 64 cart. | Extreme-G XG2 Model NUS-NG2J | 1999 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Arcade Video game | Ez2Dj The 1st Tracks | 1999 | Amuse World Corp. Seoul, Korea |
| Arcade Video game | Ez2DJ The 1st Tracks Special Edition | 1999 | Amuse World Corp. Seoul, Korea |
| Sony PlayStation CD | EZ: Ehrgeiz - God Bless the Ring Model SLUS-00809 | 1999 | Square Co., Ltd. Japan |
| Sony PlayStation CD | Élan Model SLPS-01925 | 1999 | Visco Corp. Kyoto, Japan |
| Nintendo 64 cart. | F-1 World Grand Prix II | 1999 | Video System Co., Ltd. Kyoto, Japan |
| Nintendo 64 cart. | F-1 World Grand Prix Model NUS-NFWD-NOE | 1999 | Video System Co., Ltd. Kyoto, Japan |
| PC/MS-Windows CD | F-16 Aggressor | 1999 | Virgin Interactive Ent., Ltd. UK 013715 |
| PC/MS-Windows CD | F-22 Lightning 3 | 1999 | NovaLogic |
| LodgetNet Gateway System (N64) pack. | F-Zero X | 1999 | LodgeNet |
| Sony PlayStation CD | F.A. Manager Model SLES-00416 | 1999 | Eidos Interactive |
| PC/MS-Windows CD | F/A-18 E Super Hornet | 1999 | Virgin Games, Ltd. UK 013715 |
| Sony PlayStation CD | F1 World Grand Prix - 1999 Season Model SLES-00887 | 1999 | Eidos Interactive |
| Sony PlayStation CD | F1 World Grand Prix - 1999 Season Model SLUS-01036 | 1999 | Eidos Interactive |
| Sega Dreamcast GD | F1 World Grand Prix Model T-3001D-50 | 1999 | Video System Co., Ltd. Kyoto, Japan |
| Sega Dreamcast GD | F1 World Grand Prix Model T-3001M | 1999 | Video System Co., Ltd. Kyoto, Japan |
| Sega NAOMI cart. | F355 Challenge | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
