| Sony PlayStation CD |  Eidos Model SLED-02411 | 1999 | Eidos Interactive |
| Sony PlayStation CD |  Eikan ha Kimini 4 Model SLPS-02173 | 1999 | Artdink Corp. Japan |
| Sony PlayStation CD | Eikan wa Kimi ni 4 Model SLPS-02173 | 1999 | Artdink Corp. Japan |
| Sony PlayStation CD | Eisei Meijin III - Game Creator Yoshimura Nobuhiro no Zunou Model SLPM-86199 | 1999 | Konami Co., Ltd. Japan |
| Sega Dreamcast GD | Eisei Meijin III - Game Creator Yoshimura Nobuhiro no Zunou Model T-9503M | 1999 | Konami Co., Ltd. Japan |
| Nintendo NES cart. | El Bloque Magico | 1999 | Gluk Video |
| Sony PlayStation CD |  El Tetris Un Magico Desafio Model SCES-02177 | 1999 | Sony Computer Ent. Europe SCEE |
| Sony PlayStation CD | Elan Model SLPS-01925 | 1999 | Visco Corp. Kyoto, Japan |
| Apple IIGS disk | Electric Crayon | 1999 | Polarware |
| Acorn Electron 3.5in. disk | Electron User Group #43/#44 | 1999 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #43/#44 | 1999 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #45 | 1999 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #45 | 1999 | EUG Electron User Group |
| Acorn Electron 3.5in. disk | Electron User Group #46 | 1999 | EUG Electron User Group |
| Acorn Electron 5.25in. disk | Electron User Group #46 | 1999 | EUG Electron User Group |
| Arcade Video game | Elfin | 1999 | Comad Industry Co., Ltd. Korea |
| PC/MS-Windows CD | Eliminator | 1999 | Psygnosis, Ltd. |
| Sony PlayStation CD | Eliminator Model SLES-01364 | 1999 | Psygnosis, Ltd. |
| Sony PlayStation CD | Eliminator Model SLUS-00699 | 1999 | Psygnosis, Ltd. |
| Nintendo Game Boy Color cart. | Elmo's 123s Model DMG-AE3E-USA | 1999 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Elmo's 123s Model DMG-AE3P-EUR | 1999 | NewKidCo International, Inc. |
| Nintendo Game Boy Color cart. | Elmo's ABCs Model DMG-AEAE-USA | 1999 | NewKidCo International, Inc. |
| Nintendo 64 cart. | Elmo's Letter Adventure | 1999 | NewKidCo International, Inc. |
| Nintendo 64 cart. | Elmo's Number Journey | 1999 | NewKidCo International, Inc. |
| Nintendo 64 cart. | Eltale Monsters Model NUS-NETJ | 1999 | Imagineer Co., Ltd. Japan |
| Pachislot | Elvis Presley | 1999 | IGT-Japan KK Japan |
| IBM PC/AT DOS 3.5in. disk | Elysium | 1999 | Magic Bytes Germany |
| Arcade Video game | Emergency Call Ambulance | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| PC/MS-Windows CD | Emergency Room 2 | 1999 | Legacy Interactive |
| Video Slot Machine | Enchantress | 1999 | Aristocrat Leisure Industries Pty, Ltd. |
| Arcade Video game | Endless Riches | 1999 | EN Tiger |
| IBM PC/AT DOS CD | Enemy Star | 1999 | Midas Int. Ent. |
| Bandai WonderSwan cart. | Engacho! for WonderSwan Model SWJ-NAP001 | 1999 | NAC Nihon Application Co., Ltd. Japan |
| Sony PlayStation CD | Engacho! Model SLPS-02263 | 1999 | NAC Nihon Application Co., Ltd. Japan |
| VTECH Genius Leader CX cart. | Englisch für Anfänger Model 80-28071 | 1999 | VTECH Video Technology, Ltd. |
| Pachislot | Epsilon | 1999 | Yamasa Japan |
| PC/MS-Windows CD | Escape | 1999 | May-Be Soft. Japan |
| IBM PC/AT DOS pack. | Escape | 1999 | Johnson, Matthew |
| Sega Dreamcast GD | Espion-Age-Nts Model T-38804M | 1999 | NEC Home Electronics, Ltd. |
| Sony PlayStation CD | Essential PlayStation CD Eleven Model SCED-01142 | 1999 | Sony Computer Ent. Europe SCEE |
