| Atari ST disk |  Dungeon Master Data Disk 5 - Conan and the Mountain of Tor Al'Kiir | 1999 | FTL Faster Than Light |
| Atari ST disk | Dungeon Master II - Legend of Skulldeep | 1999 | FTL Faster Than Light |
| Sega Saturn CD | Dungeon's & Dragons - Tower of Doom Dungeons & Dragons Collection Disc 1 | 1999 | Capcom Co., Ltd. Japan |
| Sega Saturn CD | Dungeons & Dragons - Shadow over Mystara Dungeons & Dragons Collection Disc 2 | 1999 | Capcom Co., Ltd. Japan |
| Arcade Video game | Duzilla | 1999 | GCTech Co., Ltd. |
| Sony PlayStation CD | DX Jinsei Game - The Game of Life III Model SLPS-02469 | 1999 | Takara Co., Ltd. Japan |
| Sony PlayStation CD | DX Shachou Game Model SLPS-02105 | 1999 | Takara Co., Ltd. Japan |
| Atari 400/800 cart. | DynaKillers | 1999 | Video 61 |
| Arcade Video game | Dynamica | 1999 | Holoplex, Inc. Pasadena, CA, USA |
| Pachislot | Dynamite | 1999 | IGT-Japan KK Japan |
| Sega NAOMI cart. | Dynamite Baseball '99 | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Dreamcast GD |  Dynamite Cop Model 51013 | 1999 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Dreamcast GD | Dynamite Cop Model MK-51013-50 | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Dynamite Deka 2 Model HDR-0020 P | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Arcade Video game | E-Jan Sakurasou - Akibeya Arimasu | 1999 | Seibu Kaihatsu, Inc. Japan |
| Sony PlayStation CD |  e-Jump Model PCPX-96178 | 1999 | Shueisha Japan |
| Nintendo 64 cart. | EA Sports Supercross 2000 Model NUS-NSXE-USA | 1999 | EA Sports |
| Sony PlayStation CD | EA Sports Supercross 2000 Model SLES-02373 | 1999 | EA Sports |
| Sony PlayStation CD | EA Sports Supercross 2000 Model SLUS-01005 | 1999 | EA Sports |
| Sony PlayStation CD | Eagle One - Harrier Attack Model SLUS-00943 | 1999 | Infogrames Ent., Inc. CA, USA 20295 |
| Nintendo Game Boy Color cart. | Earthworm Jim - Menace 2 the Galaxy Model DMG-AEBE-USA | 1999 | Crave Ent., Inc. |
| Nintendo Game Boy Color cart. | Earthworm Jim - Menace 2 the Galaxy Model DMG-AEBP-EUR | 1999 | Crave Ent., Inc. |
| Nintendo 64 cart. | Earthworm Jim 3D | 1999 | Rockstar Games |
| PC/MS-Windows CD | Earthworm Jim 3D | 1999 | Interplay |
| PC/MS-Windows CD | Eastern Front 2 | 1999 | TalonSoft |
| Sony PlayStation CD | Eberouge 2 Model SLPS-01905 | 1999 | Takara Co., Ltd. Japan |
| Sega Dreamcast GD |  Ecco 3D | 1999 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Dreamcast GD | Ecco the Dolphin - E3 Demo | 1999 | SEGA of America, Inc. San Francisco, CA, USA |
| Sony PlayStation CD | Echo Night #2 - Nemuri no Shihaisha Model SLPS-02167 | 1999 | From Soft. |
| Sony PlayStation CD | Echo Night Model SLUS-00820 | 1999 | Agetec, Inc. Sunnyvale, CA, USA |
| Sony PlayStation CD | Ecsaform Model SLPS-01791~2 | 1999 | Bandai Visual Co., Ltd. |
| PC/MS-Windows CD | Edgar Torrontera's Extreme Biker | 1999 | Havas Interactive |
| PC/MS-Windows CD | EDK4 - Ying Geet Chuen | 1999 | KOEI Co., Ltd. Japan |
| Pachislot | Edono Nezumi | 1999 | Aruze Corp. Japan |
| Nintendo Famicom cart. | Education Computer 2000 48 in 1 | 1999 | Unknown Russia |
| Sega Dreamcast GD | EGG - Elemental Gimmick Gear Model T-14302M | 1999 | Hudson Soft. Hudson Group Japan |
| Sega Dreamcast GD | EGG - Elemental Gimmick Gear Model T-41601N | 1999 | Vatical Ent. |
| Sony PlayStation CD | Eidos Demo CD Vol. 4 Model SLUS-90051 | 1999 | Eidos Interactive |
| Sony PlayStation CD | Eidos Demo CD Vol. 6 Model SLUS-90074 | 1999 | Eidos Interactive |
| Sony PlayStation CD | Eidos Demo Disc Vol. 5 Model SLUS-90065 | 1999 | Eidos Interactive |
