| PC/MS-Windows CD |  Darcrows Model ALS-0038 18 | 1999 | Alicesoft Japan |
| PC/MS-Windows CD | Dark Secrets of Africa | 1999 | T-HQ, Inc. Toy HeadQuarters |
| PC/MS-Windows CD | Dark Side of the Moon | 1999 | SouthPeak Interactive, LLC |
| PC/MS-Windows CD | Darkstone | 1999 | Gathering of Developers, Inc. |
| Pachislot | Daruma San | 1999 | Pioneer Co., Ltd. Japan |
| Sony PlayStation CD | Dead in the Water Model SLUS-00693 | 1999 | ASC Games |
| NEC PC-Engine CD | Dead of the Brain 1 & 2 Model HECD5024 18 | 1999 | NEC Home Electronics, Ltd. |
| Sega NAOMI cart. | Dead or Alive 2 | 1999 | Tecmo, Ltd. Tokyo, Japan |
| MSX 2 disk | Dead or Live | 1999 | Unknown |
| Sega Dreamcast GD | Deadly Skies Model T-9501D-50 | 1999 | Konami Co., Ltd. Japan |
| Sega Dreamcast GD | Death Crimson 2 - Meranito no Saidan Model T-23201M | 1999 | Ecole Soft. |
| Sony PlayStation CD |  Deco Pre 2 '99 Taikenban Model SLPM-80478 | 1999 | Data East Corp. Japan |
| Sony PlayStation CD | Deep Freeze Model SLPS-01817 | 1999 | Sammy Corp. Japan |
| PC/MS-Windows CD | Deer Hunter 2 | 1999 | GT Interactive Soft. Corp. NY, USA |
| PC/MS-Windows CD | Deer Hunter 3 | 1999 | GT Interactive Soft. Corp. NY, USA |
| Nintendo Game Boy Color cart. | Deer Hunter Model CGB-AXHE-USA | 1999 | Vatical Ent. |
| Nintendo 64 cart. | Defi au Tetris Magique | 1999 | Capcom Co., Ltd. Japan |
| Sony PlayStation CD |  Defi au Tetris Magique Model SCES-02174 | 1999 | Sony Computer Ent. Europe SCEE |
| Nintendo Game Boy Color cart. | Deja Vu I & II - The Casebooks of Ace Harding Model CGB-ADTE-USA | 1999 | Vatical Ent. |
| Nintendo Game Boy Color cart. | Deja Vu I & II - The Casebooks of Ace Harding Model CGB-ADTJ-JPN | 1999 | Kemco, Ltd. |
| Nintendo Game Boy Color cart. | Deja Vu I & II - The Casebooks of Ace Harding Model CGB-ADTX-EUR | 1999 | Kemco, Ltd. |
| Nintendo Game Boy Color cart. | Deja Vu I & II - The Casebooks of Ace Harding Model CGB-ADTY-EUU | 1999 | Kemco, Ltd. |
| Pachislot | Dekanana | 1999 | Bellco Corp. Japan |
| Sony PlayStation CD | Dekiru! Game Center Model SLPS-01810~1 | 1999 | Shoeisha Co., Ltd. Japan |
| PC/MS-Windows CD | Delta Force 2 | 1999 | NovaLogic |
| Sony PlayStation CD | Demo Codemasters Model SLED-02246 | 1999 | Codemasters Soft. Co., Ltd., The 015026 |
| PC/MS-Windows CD | Demolition Derby | 1999 | Astral Ent. |
| Sony PlayStation CD | Demolition Racer Model SLES-02018 | 1999 | Infogrames Europe 546430 |
| Sony PlayStation CD | Demolition Racer Model SLUS-00969 | 1999 | Infogrames Ent., Inc. CA, USA 20295 |
| Sony PlayStation CD | Dengeki PlayStation D20 Model SLPM-80438 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D21: SCE Special Model PCPX-96159 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D22 Model SLPM-80471 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D23 Model SLPM-80481 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D24 Model SLPM-80496 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D25 Model SLPM-80497 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D26 Model SLPM-80505 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D27 Model SLPM-80516 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D28 Model SLPM-80526 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D29 Model SLPM-80545 | 1999 | Media Works Japan |
| Sony PlayStation CD | Dengeki PlayStation D30 Model SLPM-80547 | 1999 | Media Works Japan |
