| Sinclair ZX Spectrum cass. |  Seymour Goes to Hollywood Model 2666 | 1991 | Codemasters Soft. Co., Ltd., The 015026 |
| Sinclair ZX Spectrum cass. | Shadow Dancer | 1991 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | Shadow Dancer + Alien Storm Model 551318 P | 1991 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | Sharkey's Moll | 1991 | Zeppelin Games |
| Sinclair ZX Spectrum cass. |  Shinobi Model 210816 P | 1991 | Mastertronic Plus UK 012967 |
| Sinclair ZX Spectrum cass. | Silverwolf | 1991 | GI Games |
| Sinclair ZX Spectrum cass. | Six Appeal Model 004443 | 1991 | UBI Soft Creteil, France 307211 |
| Sinclair ZX Spectrum cass. | Skull & Crossbones Model 653-X | 1991 | Domark Group, Ltd. |
| Sinclair ZX Spectrum cass. | Sky High Stuntman Model 2504 | 1991 | Codemasters Soft. Co., Ltd., The 015026 |
| Sinclair ZX Spectrum cass. | Slightly Magic Model 2446 | 1991 | Codemasters Soft. Co., Ltd., The 015026 |
| Sinclair ZX Spectrum cass. | Smaily Model SM-021-SPE | 1991 | Zigurat Soft. Spain |
| Sinclair ZX Spectrum cass. | Smash T.V. P | 1991 | Ocean Soft., Ltd. 13156 |
| Sinclair ZX Spectrum cass. |  Smash T.V. | 1991 | Erbe Soft. Spain |
| Sinclair ZX Spectrum cass. | Snow Joke! | 1991 | Zenobi Soft. |
| Sinclair ZX Spectrum cass. | Soccer Double | 1991 | E&J Soft. |
| Sinclair ZX Spectrum cass. | Soccer Double | 1991 | Challenge Soft. |
| Sinclair ZX Spectrum cass. | Soccer Double 2 | 1991 | Challenge Soft. |
| Sinclair ZX Spectrum cass. | Soccer Double 3 | 1991 | Challenge Soft. |
| Sinclair ZX Spectrum cass. | Soccer Rematch - Italia 90 | 1991 | Lambourne Games |
| Sinclair ZX Spectrum cass. | Soccer Rivals | 1991 | Cult |
| Sinclair ZX Spectrum cass. | Space Harrier II | 1991 | Unique |
| Sinclair ZX Spectrum cass. | Spectrum Adventure Starter Pack | 1991 | Tartan Soft. |
| Sinclair ZX Spectrum cass. | Speedway Replay | 1991 | Lambourne Games |
| Sinclair ZX Spectrum cass. | Spellbound Dizzy Model 2664 | 1991 | Codemasters Soft. Co., Ltd., The 015026 |
| Sinclair ZX Spectrum cass. | Spike in Transylvania Model 2461 | 1991 | Codemasters Soft. Co., Ltd., The 015026 |
| Sinclair ZX Spectrum cass. | Spooky Castle | 1991 | Atlantis Soft. |
| Sinclair ZX Spectrum cass. | Sports Collection 18: Skate Wars | 1991 | Hit Squad, The UK 13156 |
| Sinclair ZX Spectrum cass. | Stack Up | 1991 | Zeppelin Games |
| Sinclair ZX Spectrum cass. | Star Bowls | 1991 | Zigurat Soft. Spain |
| Sinclair ZX Spectrum cass. | Star Control | 1991 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sinclair ZX Spectrum cass. | Star Flaws | 1991 | Delbert the Hamster Soft. |
| Sinclair ZX Spectrum cass. | Star Flaws & Raymond Pringle's Quest For The Fabled Jar Of Pickled Cabbage | 1991 | Delbert the Hamster Soft. |
| Sinclair ZX Spectrum cass. | Star Trip | 1991 | Pegasus Soft. |
| Sinclair ZX Spectrum cass. | Stifflip & Co. Model 546680 | 1991 | Kixx 013442 |
| Sinclair ZX Spectrum cass. | Strange Tale | 1991 | Advanced Adventure Creations Spain |
| Sinclair ZX Spectrum cass. | Stratford Depotmaster | 1991 | Greenup, Ashley |
| Sinclair ZX Spectrum cass. | Striker Manager | 1991 | Cult |
| Sinclair ZX Spectrum cass. | SU issue 107: Six of the Best 3 | 1991 | Sinclair User |
| Sinclair ZX Spectrum cass. | SU issue 108: Six of the Best 4 | 1991 | Sinclair User |
| Sinclair ZX Spectrum cass. | SU issue 109: Great Eight 1 | 1991 | Sinclair User |
