| Amstrad CPC pack. |  Death Stalker | 1991 | EDOS Electronic Distribution of Software |
| Commodore Amiga 500 disk |  Deathbringer | 1991 | Empire Interactive Europe, Ltd. |
| Sega Mega Drive cart. |  DecapAttack | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | DecapAttack Model 1027-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Genesis cart. | DecapAttack Model 1027 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Samsung Super Gam*Boy cart. | DecapAttack Model GM4043JG | 1991 | Samsung Korea |
| Amstrad CPC pack. | Deep Strike | 1991 | EDOS Electronic Distribution of Software |
| Sinclair ZX Spectrum cass. | Deep Waters 1 | 1991 | Zenobi Soft. |
| Commodore Amiga CDTV CD | Defender of the Crown CDTV | 1991 | Commodore, Ltd. |
| Commodore Amiga 500 pack. | Defender of the Crown Model 859 | 1991 | EDOS Electronic Distribution of Software |
| Atari ST pack. | Defender of the Crown Model 859 | 1991 | EDOS Electronic Distribution of Software |
| IBM PC DOS pack. | Defender of the Crown Model 859 | 1991 | EDOS Electronic Distribution of Software |
| Nintendo NES cart. | Defender of the Crown Model NES-U3-EEC | 1991 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Defender of the Crown Model NES-U3-FRA | 1991 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Defender of the Crown Model NES-U3-ITA | 1991 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Defender of the Crown Model NES-U3-NOE | 1991 | Palcom Soft., Ltd. |
| Nintendo NES cart. | Defender of the Crown Model NES-U3-UKV | 1991 | Palcom Soft., Ltd. |
| Sharp X68000 Series 5.25in. disk | Deflektor | 1991 | BPS Bullet-Proof Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Deflektor | 1991 | BPS Bullet-Proof Soft. Japan |
| NEC PC-8801 Series disk | Deflektor Model BP10031030 | 1991 | BPS Bullet-Proof Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Deja Vu - A Nightmare Comes True Model PS-34 | 1991 | Pack-In-Video Co., Ltd. Japan |
| NEC PC-9801 Series 3.5in. disk | Deja Vu - A Nightmare Comes True Model PS-35 | 1991 | Pack-In-Video Co., Ltd. Japan |
| IBM PC 3.5in. disk | Delen | 1991 | HVB Soft. |
| Amstrad CPC 464 disk | Demo 6 Hb | 1991 | DSC |
| Sharp X68000 Series 5.25in. disk | Demon Slayer 3 | 1991 | T&H Project |
| Elektronika BK0010 cass. | Demon Stalker | 1991 | KV |
| Commodore Amiga 500 disk | Demon Wars | 1991 | CompuTec Verlag |
| Commodore Amiga 500 disk | Demoniak | 1991 | Palace Soft. 013518 |
| Atari ST disk | Demoniak | 1991 | Palace Soft. 013518 |
| Commodore Amiga 500 pack. | Denaris Model 871 | 1991 | EDOS Electronic Distribution of Software |
| NEC PC-9801 Series 5.25in. disk | Dennou Gakuen 4 - Ape Hunter J | 1991 | Gainax Japan |
| NEC PC-9801 Series 3.5in. disk | Dennou Gakuen 4 - Ape Hunter J | 1991 | Gainax Japan |
| Commodore C64 disk | Der Preis ist Heiss | 1991 | GameTek, Inc. Miami Beach, FL, USA 43948 |
| Video Slot Machine | Derby Day | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| IBM PC 3.5in. disk | Desafio Final | 1991 | Ediciones Manali, S.A. |
| Sinclair ZX Spectrum+3 disk | Desafio Total | 1991 | Erbe Soft. Spain |
| Commodore C64 type-in | Desdemona | 1991 | Compute! Publications, Inc. |
| Arcade Video game | Desert Assault | 1991 | Data East Corp. Japan |
| Sega Mega Drive 32X cart. | Desert Attack Helicopter | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sinclair ZX Spectrum cass. | Desert Island | 1991 | GI Games |
