| Sinclair ZX Spectrum cass. |  Diablo! | 1988 | Nebula Designs Soft. |
| Sinclair ZX Spectrum cass. | Diamond Model URK 903 | 1988 | Destiny Soft. |
| Sinclair ZX Spectrum cass. | Dixons Premier Collection For Your +2 | 1988 | Dixons |
| Sinclair ZX Spectrum cass. | Doctor Goo and the Samorons | 1988 | Global Games Scotland |
| Sinclair ZX Spectrum cass. | Don't Say It, Spray It | 1988 | Pirate Soft. |
| Sinclair ZX Spectrum cass. |  Doombase | 1988 | System 4 de Espana, S.A. Spain |
| Sinclair ZX Spectrum cass. | Downhill Champion | 1988 | Lambourne Games |
| Sinclair ZX Spectrum cass. | Dr. Jekyll and Mr. Hyde | 1988 | Essential Myth, The |
| Sinclair ZX Spectrum cass. | Draconus Model S034 | 1988 | Zeppelin Games |
| Sinclair ZX Spectrum cass. | Dragonia | 1988 | Astros Productions |
| Sinclair ZX Spectrum cass. | Dream Warrior | 1988 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | Driver 2 - Leeds - Settle - Carlisle | 1988 | Greenup, Ashley |
| Sinclair ZX Spectrum cass. | Droidz | 1988 | Silverbird Soft. 012439 |
| Sinclair ZX Spectrum cass. | Dun Darach Model 2MT129 | 1988 | Dro Soft. Madrid, Spain |
| Sinclair ZX Spectrum cass. | Dusty Droid and the Garbage Gobblers Model PSAC 106 | 1988 | Pirate Soft. |
| Sinclair ZX Spectrum cass. | Dyna Star | 1988 | Pirate Soft. |
| Sinclair ZX Spectrum cass. | Earthlight Model 011897 | 1988 | Firebird Soft. UK 012439 |
| Sinclair ZX Spectrum cass. | Echelon | 1988 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | El Equipo A Model 60110647 | 1988 | Zafiro Soft. Div. Spain |
| Sinclair ZX Spectrum cass. | El Mundo Perdido | 1988 | Topo Soft. Spain |
| Sinclair ZX Spectrum cass. | El Poder Oscuro Model PO-002-SPE | 1988 | Zigurat Soft. Spain |
| Sinclair ZX Spectrum cass. | Eliminator Model 010632 | 1988 | Hewson Consultants, Ltd. England 012635 |
| Sinclair ZX Spectrum cass. | Eliminator Model AS 201 | 1988 | Alternative Soft., Ltd. |
| Sinclair ZX Spectrum cass. | Emilio Butragueno Futbol | 1988 | Topo Soft. Spain |
| Sinclair ZX Spectrum cass. | Endzone - 88e Rosters + Program | 1988 | Sport-Sim |
| Sinclair ZX Spectrum cass. | Endzone - 88f Rosters | 1988 | Sport-Sim |
| Sinclair ZX Spectrum cass. | Enter at Your Own Risk | 1988 | Teenware |
| Sinclair ZX Spectrum cass. | Era of Enchantment | 1988 | Sacred Scroll Soft. |
| Sinclair ZX Spectrum cass. | Erbe 88 | 1988 | Erbe Soft. Spain |
| Sinclair ZX Spectrum cass. |  Escape from Khoshima | 1988 | Atlantis Soft. |
| Sinclair ZX Spectrum cass. | Escape from Magic | 1988 | Stewart, Eric |
| Sinclair ZX Spectrum cass. | Escape from the Shire | 1988 | D.N.D. Soft. |
| Sinclair ZX Spectrum cass. | Espionage | 1988 | Grandslam Ent., Ltd. |
| Sinclair ZX Spectrum cass. | European 5-a-Side | 1988 | Silverbird Soft. 012439 |
| Sinclair ZX Spectrum cass. | European Champions Model 9004 | 1988 | E&J Soft. |
| Sinclair ZX Spectrum cass. | Evaristo el Punky Model 1 STY 613 | 1988 | SPE Spain |
| Sinclair ZX Spectrum cass. | Every Second Counts | 1988 | TV Games |
| Sinclair ZX Spectrum cass. | Evil Domain | 1988 | R&H Microtec |
| Sinclair ZX Spectrum cass. | Exploding Fist + Model 000314 | 1988 | Firebird Soft. UK 017096 |
| Sinclair ZX Spectrum cass. | Explorer XXXI Model 2MT 089 | 1988 | Dro Soft. Madrid, Spain |
