| IBM PC 5.25in. disk |  Alf - The First Adventure | 1988 | Box Office Soft. |
| Apple IIc+ 3.5in. disk |  Alge-Blaster! | 1988 | Davidson & Associates, Inc. |
| MSX 2 cart. | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| NEC PC-9801 Series 5.25in. disk | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| NEC PC-8801 Series disk | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| MSX 2 disk | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| NEC PC-9801 Series 3.5in. disk | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| Sharp X1 5.25in. disk | Algeese no Tsubasa - Youka Ankoku-Hen | 1988 | Kogado Studio Japan |
| Commodore C16 cass. | Algoritmusok + Játékok | 1988 | Vorker Hungary |
| IBM PC 5.25in. disk | Aliants - The Desperate Battle for Earth! | 1988 | Keypunch Soft. |
| Sega AI Computer cart. | Alice World Model AI-4051 | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sharp X68000 type-in | Alien | 1988 | Dempa Shinbunsha Japan |
| Amstrad CPC cass. | Alien 8 Model 3MT146 | 1988 | Dro Soft. Madrid, Spain |
| Amstrad CPC type-in | Alien Attack | 1988 | Schneider Computer Partner |
| NEC PC-Engine HuCARD | Alien Crush Model NX63001 | 1988 | Naxat Soft. Japan |
| NEC PC-6001 type-in | Alien Crush! | 1988 | Dempa Shinbunsha Japan |
| Sharp PC-1245 type-in | Alien Kill | 1988 | Dempa Shinbunsha Japan |
| Apple IIGS disk | Alien Mind | 1988 | PBI Soft., Inc. Foster City, CA, USA |
| MSX cass. | Alien Syndrome | 1988 | Dro Soft. Madrid, Spain |
| Sinclair ZX Spectrum+3 disk |  Alien Syndrome | 1988 | Dro Soft. Madrid, Spain |
| Sinclair ZX Spectrum+3 disk | Alien Syndrome | 1988 | ACE Soft. |
| Atari ST disk | Alien Syndrome | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Commodore C64 cass. | Alien Syndrome | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Master System cart. | Alien Syndrome Model 7006 P | 1988 | Tonka Corp. MN, USA |
| Sinclair ZX Spectrum cass. | Alien Syndrome Model ACE235C | 1988 | ACE Soft. |
| Commodore Amiga 500 disk | Alien Syndrome Model ACE23AG | 1988 | ACE Soft. |
| Sega Master System cart. | Alien Syndrome Model MK-7006-50 P | 1988 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Amstrad CPC cass. | Alien Syndrome Model RAD1AM | 1988 | Softek International, Ltd. |
| Nintendo Famicom cart. | Alien Syndrome Model SAN-AZ P | 1988 | SUNSOFT Kounan, Japan |
| NEC PC-9801 Series 5.25in. disk | Alien Zukan | 1988 | Brain Gray Co., Ltd. Japan |
| Amstrad CPC type-in | Aligator | 1988 | Laser Press SARL Saint-Mandé, France |
| Apple IIGS disk | All About America | 1988 | Unicorn Soft. |
| NEC PC-Engine HuCARD | All Star Power League | 1988 | Hudson Soft. Hudson Group Japan |
| Sinclair ZX Spectrum cass. | All Stars | 1988 | Edge, The |
| Amstrad CPC 464 disk | All-Stars | 1988 | Edge, The |
| Medal video game | Almond Pinky | 1988 | Dynax, Inc. Nagoya, Japan |
| Amstrad CPC type-in | Alpha Jet | 1988 | Magazin Gamebox Germany |
| Arcade Video game | Alpha One | 1988 | Vision Electronics |
| Commodore Amiga 500 disk | Alpha-1 | 1988 | ECP Entertainment & Computer Products Pty. Ltd. |
| Amstrad CPC type-in | Alpha-Strip | 1988 | Editions SORACOM France |
