| Apple Macintosh disk |  Deja Vu II - Lost in Las Vegas!! | 1988 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Sinclair ZX Spectrum cass. | Delfox Model SPE 880011 | 1988 | Dinamic Soft. Madrid, Spain |
| Commodore C64 disk | Delight Boulder Dash 1 Hb | 1988 | No One |
| Commodore C64 disk | Delight Boulder Dash 2 Hb | 1988 | No One |
| VEB Mikroelektronik KC cass. | Deliro | 1988 | VEB Mikroelektronik |
| Arcadia Super Select board | Delta Command | 1988 | Arcadia Systems, Inc. Mastertronic Group Costa Mesa, CA, USA |
| Commodore C64 disk | Deluxe-Quadromania | 1988 | Markt & Technik |
| Amstrad CPC 464 disk | Demo 3 Hb | 1988 | Katto Cracking |
| Amstrad CPC 464 disk | Demo 4 Hb | 1988 | Katto Cracking |
| Amstrad CPC 464 disk | Demo Sound Track Hb | 1988 | BCVA |
| Sord M.5 BASIC-G type-in | Demon | 1988 | Dempa Shinbunsha Japan |
| Atari 400/800 type-in | Demon Racer | 1988 | ANTIC Publishing |
| Sinclair ZX Spectrum cass. | Demon's Dream | 1988 | Redefine Keys |
| Amstrad CPC cass. | Demon's Revenge Model LM-009 | 1988 | MCM Soft. Spain |
| IBM PC 5.25in. disk | Demon's Winter | 1988 | SSI Strategic Simulations, Inc. 16685 |
| Commodore C64 disk |  Demon's Winter | 1988 | ECP Entertainment & Computer Products Pty. Ltd. |
| MSX type-in | Dempa de Panic II | 1988 | Dempa Shinbunsha Japan |
| NEC PC-8001 type-in | Dempa Fighter | 1988 | Dempa Shinbunsha Japan |
| Commodore C64 cass. | Denaris | 1988 | Rainbow Arts |
| Sinclair ZX Spectrum cass. | Denizen | 1988 | Players Soft. |
| MSX 2 disk | Dennou Gakuen II - Highway Buster | 1988 | Gainax Japan |
| Sharp X68000 Series 5.25in. disk | Dennou Sakka - Cyber Writer Scenario Shuu 1 | 1988 | Nihon Computer Club Renmei Kikaku |
| Sharp X68000 Series 5.25in. disk | Dennou Sakka - Cyber Writer ver 2.0 | 1988 | Nihon Computer Club Renmei Kikaku |
| Nintendo Famicom cart. | Densetsu no Kishi ELROND Model NMK-ER | 1988 | JALECO Co., Ltd. Japan |
| MSX type-in | Denwa-kun | 1988 | Dempa Shinbunsha Japan |
| NEC PC-8001 type-in | Deos-II | 1988 | Dempa Shinbunsha Japan |
| Sharp MZ-2000 type-in | Departure - I may not meet you again | 1988 | Dempa Shinbunsha Japan |
| Amstrad CPC 464 disk | Der Zeichner Hb | 1988 | Silly Soft |
| NEC PC-9801 Series 5.25in. disk | Derringer 18 | 1988 | Jast Japan |
| MSX 2 disk | Derringer | 1988 | Jast Japan |
| Amstrad CPC cass. | Dervish | 1988 | Power House, The UK |
| Atari XE cart. | Desert Falcon Model RX8089 | 1988 | Atari Corp. CA, USA |
| Apple IIGS disk | Designasaurus | 1988 | DesignWare |
| Apple II 5.25 disk | Designasaurus | 1988 | DesignWare |
| Commodore C64 disk | Designasaurus | 1988 | DesignWare |
| Chess board | Designer 2100 Model 6103 | 1988 | Fidelity Electronics |
| Acorn Archimedes disk | Desk Top Stories | 1988 | Resource |
| Sinclair ZX Spectrum cass. | Desolator | 1988 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | Desolator | 1988 | Erbe Soft. Spain |
| Commodore C64 cass. | Desolator - Halls of Kyros | 1988 | US Gold, Ltd. Birmingham, England 13442 |
