| Google Play pack. |  Scooby-Doo! Mystery Cases | 2018 | Warner Bros. Ent., Inc. |
| Google Play pack. | Score! Match | 2018 | First Touch Games, Ltd. |
| PC/MS-Windows CD | Scum | 2018 | Devolver Digital |
| Nintendo Switch cart. | SD Gundam G Generation Genesis Model LA-H-AMSTA-JPN | 2018 | Bandai NAMCO Ent., Inc. |
| PC/MS-Windows CD | Sea of Thieves | 2018 | Microsoft |
| Google Play pack. | Seattle Pie Truck | 2018 | Tapps Games |
| Colecovision cart. | Secret of the Moai Hb | 2018 | Team Pixelboy |
| Google Play pack. | SEGA Heroes | 2018 | SEGA Corp. |
| Arcade Video game | SEGA World Drivers Championship | 2018 | SEGA Corp. |
| Arcade Video game | SEGA World Drivers Championship 2019 | 2018 | SEGA Corp. |
| Sony PlayStation 4 BR | Seiken Densetsu 2 Model PLJM-16069 | 2018 | Square Enix Co., Ltd. Japan |
| Sony PS Vita game | Seiken Densetsu 2 Model VLJM-38041 | 2018 | Square Enix Co., Ltd. Japan |
| Slot Machine | Seinfeld | 2018 | Scientific Games Taipa, Macau |
| PC/MS-Windows pack. | Semblance | 2018 | GOG sp. z o.o. |
| Google Play pack. | Semi Heroes | 2018 | Divmob |
| Pachislot | Sencolle! Taihei Onna - Ieyasu Tokugawa | 2018 | Konami Amusement Co., Ltd. Japan |
| Nintendo Switch cart. | Senjou no Valkyria 4 Model LA-H-APSBA-JPN | 2018 | SEGA Corp. |
| Sony PlayStation 4 BR | Senjou no Valkyria 4 Model PLJM-16100 | 2018 | SEGA Holdings Co., Ltd. |
| Sony PlayStation 4 BR | Senran Kagura Burst Re:Newal Model PLJM-16074 | 2018 | Marvelous Ent., Inc. |
| PC/MS-Windows pack. | SEUM - Speedrunners from Hell | 2018 | GOG sp. z o.o. |
| PC/MS-Windows CD | Shadow of the Tomb Raider | 2018 | Square Enix Co., Ltd. Japan |
| PC/MS-Windows pack. |  Shadow of the Tomb Raider Trial Model 974630 | 2018 | Steam Valve Corp. |
| PC/MS-Windows pack. | Shadow of the Tomb Raider Model 750920 | 2018 | Steam Valve Corp. |
| PC/MS-Windows CD | Shadows - Awakening | 2018 | Kalypso Media GmbH |
| PC/MS-Windows pack. | Shadows - Awakening | 2018 | GOG sp. z o.o. |
| Nintendo Switch cart. | Shanghai Refresh | 2018 | SUNSOFT Kounan, Japan |
| Sony PlayStation 4 BR | Shantae - Half Genie Half Hero Ultimate Edition Model PLJM-16165 | 2018 | Oizumi Amuzio Japan |
| Nintendo Switch cart. |  Shantae - Half-Genie Hero - Ultimate Edition | 2018 | XSEED Games |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGA-EUR | 2018 | PQube, Ltd. |
| Nintendo Switch cart. | Shantae - Half-Genie Hero - Ultimate Edition Model LA-H-AMSGB-JPN | 2018 | Oizumi Amuzio Japan |
| PC/MS-Windows pack. | Shantae - Half-Genie Hero Ultimate Edition | 2018 | GOG sp. z o.o. |
| Nintendo Switch cart. | Shantae and the Pirate's Curse | 2018 | Limited Run Games |
| PC/MS-Windows pack. | Shaq Fu - A Legend Reborn | 2018 | GOG sp. z o.o. |
| PC/MS-Windows pack. | Shards of Eradine Model 804830 | 2018 | Steam Valve Corp. |
| Nintendo Switch cart. | Shelter Generations | 2018 | Super Rare Games |
| Sony PlayStation 4 BR | Shenmue I & II Model CUSA-10559 | 2018 | SEGA Holdings Co., Ltd. |
| PC/MS-Windows pack. | Sherlock Holmes - The Devil's Daughter | 2018 | GOG sp. z o.o. |
| Sony PlayStation 4 BR | Shiawase sou no Kanrijin-san Model PLJS-70054 | 2018 | D3 Publisher, Inc. |
| Nintendo Switch cart. | Shiin Model LA-H-AN62A-JPN | 2018 | Experience, Inc. Japan |
| Nintendo Switch cart. | Shikhondo - Soul Eater Model EAS-SW003 | 2018 | EastAsiaSoft |
