| Amstrad CPC type-in |  Defender | 1986 | Tronic-Verlag GmbH |
| Commodore Amiga 500 disk | Defender of the Crown Model 85221 | 1986 | Cinemaware Corp. |
| MSX type-in | Deffon | 1986 | Dempa Shinbunsha Japan |
| Commodore C64 disk | Definitions | 1986 | Alpha Soft. |
| Commodore C64 cart. | Deflection P | 1986 | Alpha Soft. |
| Commodore Amiga 500 disk | Deja Vu - A Nightmare Comes True Model 85137 | 1986 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Apple Macintosh disk | Deja Vu - A Nightmare Comes True Model 85186 | 1986 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Sinclair ZX Spectrum cass. | Dekorating Blues | 1986 | Alpha-Omega Soft., Ltd. |
| Acorn BBC/Electron cass. | Deltic Fleet Manager | 1986 | Dee-Kay Systems |
| Sinclair ZX Spectrum cass. | Deltic Fleet Manager | 1986 | Dee-Kay Systems |
| Amstrad CPC 464 disk | Deltic Fleet Manager A Railway Simulation | 1986 | Dee-Kay Systems |
| Amstrad CPC 464 disk | Demain Holocauste | 1986 | Chip Paris, France |
| Sinclair ZX Spectrum cass. | Demon from the Darkside | 1986 | Compass Soft. |
| MSX cass. | Demonia I - L'Intrusion | 1986 | Microïds |
| Coleco Adam disk | Demons & Dragons | 1986 | Fast Ed's Soft. |
| Sharp PC-1245 type-in | Demons' Tower | 1986 | Dempa Shinbunsha Japan |
| Amstrad CPC cass. | Dempsey and Makepeace | 1986 | Britannia Soft., Ltd. |
| Amstrad CPC 464 disk | Departements Francais Hb | 1986 | Alpesoft |
| Thomson MO5 cass. | Departge | 1986 | Ecole Jules Ferry |
| Commodore C64 disk | Depth Charge | 1986 | Alpha Soft. |
| Commodore C64 disk | Der Kleine Hobbit | 1986 | Markt & Technik |
| Hitachi MB-6880 (BM-LII) type-in | Derailway Game | 1986 | Dempa Shinbunsha Japan |
| Amstrad CPC cass. | Desert Fox | 1986 | Power House, The UK |
| Amstrad CPC cass. | Desert Fox | 1986 | US Gold, Ltd. Birmingham, England 13442 |
| Amstrad CPC 464 disk | Desert Fox | 1986 | US Gold, Ltd. Birmingham, England 13442 |
| Commodore C64 cass. | Desert Fox | 1986 | US Gold, Ltd. Birmingham, England 13442 |
| Sinclair ZX Spectrum cass. | Desert Hawk | 1986 | Players Soft. |
| Commodore C64 cass. | Desert Hawk | 1986 | Players Soft. |
| Atari ST disk | Desolator | 1986 | US Gold, Ltd. Birmingham, England 13442 |
| MSX cass. | Desolator Model 013075 | 1986 | Gremlin Graphics Soft., Ltd. 013658 |
| Atari 400/800 cass. | Despatch Rider | 1986 | Mastertronic, Ltd. UK 012967 |
| Atari 400/800 disk | Despatch Rider | 1986 | Mastertronic, Ltd. UK 012967 |
| Sinclair ZX Spectrum cass. | Desperado Model CSC 6 | 1986 | Central Solutions, Ltd. |
| Thomson TO7 type-in | Dessin | 1986 | Sybex France |
| MSX cass. | Destroyer | 1986 | Mind Games Espana, S.A. |
| Commodore C64 disk | Destroyer | 1986 | Epyx, Inc. Redwood City, CA, USA |
| Apple II 5.25 disk | Destroyer | 1986 | Epyx, Inc. Redwood City, CA, USA |
| IBM PC 5.25in. disk | Destroyer | 1986 | Epyx, Inc. Redwood City, CA, USA |
| Video Slot Machine | Deuces Wild | 1986 | ACE American Coin Enterprises USA |
| Amstrad CPC cass. | Deutschstunde 1 Model 750 528.0 | 1986 | Europa Computer Club |
