| TRS-80 CoCo cart. |  Castle Guard Model 26-3079 | 1981 | Tandy Corp. |
| Apple II 5.25 disk | Castle Smurfenstein | 1981 | Dead Smurf |
| Apple II 5.25 disk | Castle Wolfenstein | 1981 | MUSE Soft. Micro Users Soft. Exchange |
| Apple II 5.25 disk | Castles of Darkness | 1981 | Cashen, Michael J. |
| Pinball | Catacomb | 1981 | Stern Electronics, Inc. Elk Grove Village, IL, USA |
| Atari 400/800 type-in | Catacombs of the Phantoms | 1981 | SoftSide Publications, Inc. |
| Sinclair ZX-81 cass. | Catacombs Model 3 | 1981 | Greye Soft., J.K. UK |
| Arcade Video game |  Catch Match | 1981 | Taito do Brazil |
| Pinball | Cavaleiro Negro | 1981 | Taito do Brazil |
| Atari 400/800 cass. | Caverns of Mars | 1981 | APX Atari Program Exchange |
| Apple II 5.25 disk | Ceiling Zero | 1981 | Turnkey Soft. |
| Pinball | Centaur Model 1239 | 1981 | Bally Mfg. Co. Chicago, IL, USA |
| Applied Technology Microbee cass. | Centipede Attack | 1981 | Dubois & McNamara Soft. |
| Arcade Video game | Centipede Cabaret model | 1981 | Atari, Inc. CA, USA |
| Arcade Video game | Centipede Cocktail 13in. model | 1981 | Atari, Inc. CA, USA |
| Arcade Video game | Centipede Cocktail 19in. model | 1981 | Atari, Inc. CA, USA |
| Arcade Video game | Centipede Upright model | 1981 | Atari, Inc. CA, USA |
| Atari 400/800 cass. | Centrale Nucleaire Model CX 4123C | 1981 | Atari PECF Creteil, France |
| Atari 400/800 cass. | Centurion | 1981 | APX Atari Program Exchange |
| Handheld game | Challenge Racer Model 3214 | 1981 | Actronics |
| Sharp MZ-80K type-in | Challenge the Pentomino | 1981 | Dempa Shinbunsha Japan |
| Arcade Video game | Challenger | 1981 | Centuri, Inc. Hialeah, FL, USA |
| Handheld game | Champion Racer Model 8107 | 1981 | Bandai Co., Ltd. Japan |
| Chess board | Champion Sensory Chess Challenger | 1981 | Fidelity Electronics |
| Handheld game | Championship Baseball Model 60-2154 | 1981 | Tandy Corp. |
| Handheld game | Championship Football Model 60-2150 | 1981 | Tandy Corp. |
| Handheld game | Championship Football Model 60-2151 | 1981 | Tandy Corp. |
| Atari 400/800 type-in | Changing Hearts | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Changing Hearts | 1981 | EMAP East Midlands Allied Press |
| Atari 400/800 cass. | Chase Games Model CS-7006 | 1981 | Creative Computing Soft. |
| Atari 400/800 disk | Chase Games Model CS-7511 | 1981 | Creative Computing Soft. |
| Bally Astrocade type-in | Chase III | 1981 | Keller, Mark S. |
| Handheld game | Chasse a l'homme | 1981 | Ludotronic France |
| Handheld game | Chef Model FP-24 | 1981 | Nintendo Co., Ltd. Japan |
| TRS-80 type-in | Chemistry Drill | 1981 | SoftSide Publications, Inc. |
| Apple II type-in | Chemistry Drill P | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Chemistry Drill P | 1981 | SoftSide Publications, Inc. |
| Sinclair ZX-81 cass. | Chess | 1981 | Psion |
| Radofin 1292 Advanced Programmable Video System cart. | Chess P | 1981 | Radofin Electronics Germany |
| Sinclair ZX-81 cass. | Chess also Chess-Clock | 1981 | Sinclair Research, Ltd. |
