| Sharp MZ-80K type-in |  SOS Bathyscaphe | 1981 | Kohgaku-Sha Co.,Ltd. |
| Bally Astrocade cass. | Sound Trek | 1981 | Fabris, Robert San Jose, CA, USA |
| Apple II 5.25 disk | Southern Command | 1981 | SSI Strategic Simulations, Inc. 16685 |
| TRS-80 cass. | Space Ace 21 | 1981 | Synergistic Solar, Inc. |
| Apple II 5.25 disk | Space Adventure - Episode One | 1981 | Sierra Soft. |
| Mattel Intellivision cart. | Space Armada Model 3759 | 1981 | Mattel Electronics Mattel, Inc. |
| TRS-80 CoCo cart. | Space Assault | 1981 | Tandy Corp. |
| TRS-80 disk | Space Assault Model 26-3060 | 1981 | Tandy Corp. |
| Watch game | Space Attacker | 1981 | Nelsonic Industries |
| Arcade Video game |  Space Battle | 1981 | Game World, Ltd. Nottingham, England |
| Bally Astrocade type-in | Space Battle | 1981 | Keller, Mark S. |
| Arcade Video game | Space Bugger | 1981 | GAT Game-A-Tron New Britain, CT, USA |
| Atari 2600 cart. | Space Cavern Model AP2002 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Atari 2600 cart. | Space Cavern PAL Model AP-2002 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Bally Astrocade type-in | Space Checkers | 1981 | L&M Soft. Newburgh, IN, USA |
| TRS-80 CoCo cass. | Space Colony Model 060-0053 | 1981 | Adventure International |
| Apple II 5.25 disk | Space Conquerors | 1981 | Softsmith Soft. |
| Arcade Video game | Space Cruiser | 1981 | Taito Corp. Japan |
| Arcade Video game | Space Dungeon | 1981 | Taito America Corp. Elk Grove Village, IL, USA |
| Atari 400/800 disk | Space Eggs | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Apple II 5.25 disk | Space Eggs | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Apple II 5.25 disk | Space Evacuation | 1981 | DynaComp, Inc. |
| Atari 400/800 disk | Space Evacuation | 1981 | DynaComp, Inc. |
| TRS-80 disk | Space Evacuation | 1981 | DynaComp, Inc. |
| Acorn Atom cass. | Space Fighter | 1981 | Program Power |
| Arcade Video game | Space Fortress | 1981 | Century Electronics, Ltd. England |
| Bally Astrocade cart. | Space Fortress Model 2012 P | 1981 | Astrocade, Inc. |
| Arcade Video game | Space Fury | 1981 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Apple II 5.25 disk | Space Games - Appointment at Aldebaran and Procyon Warrior | 1981 | Synergistic Soft. Bellevue, WA, USA |
| Mattel Intellivision cart. | Space Hawk Model 5136 | 1981 | Mattel Electronics Mattel, Inc. |
| Sinclair ZX-81 cass. | Space Intruders | 1981 | Hewson Consultants, Ltd. England 012635 |
| TRS-80 cass. | Space Intruders Model 010-0116 | 1981 | Adventure International |
| TRS-80 disk | Space Intruders Model 012-0116 | 1981 | Adventure International |
| Sharp MZ-80K type-in | Space Invader | 1981 | Kohgaku-Sha Co.,Ltd. |
| Entex Select-A-Game cart. | Space Invader 2 | 1981 | Entex Industries, Inc. Compton, CA, USA |
| Handheld game | Space Invader Model COP444 | 1981 | Entex Industries, Inc. Compton, CA, USA |
| Sinclair ZX-81 cass. | Space Invaders | 1981 | DK Tronics |
| Tabletop game | Space Invaders | 1981 | Tiger Electronic Toys, Inc. Orchard Mundelein, IL, USA |
| TRS-80 cass. | Space Invaders | 1981 | Sivea S.A. Paris, France |
| Sharp MZ-80B type-in | Space Invaders P | 1981 | Kohgaku-Sha Co.,Ltd. |
