| Apple II 5.25 disk |  Adventure of the Month #7: Black Hole Adventure | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 disk | Adventure on a Boat | 1981 | SubLOGIC Corp. Champaign, IL, USA |
| Texas instrument TI-99/4A cart. | Adventure Model PHM 3041 | 1981 | Texas Instruments |
| Texas instrument TI-99/4A cass. | Adventureland Model PHT 6046 | 1981 | Texas Instruments |
| Commodore VIC-20 cart. | Adventureland Model VIC-1914 | 1981 | Commodore, Ltd. |
| Acorn Atom cass. | Adventures | 1981 | Acornsoft, Ltd. England |
| TRS-80 disk |  Adventures #1~#3 Model CS-3516 | 1981 | Creative Computing Soft. |
| TRS-80 disk | Adventures #4~#6 Model CS-3517 | 1981 | Creative Computing Soft. |
| Apple II 5.25 disk | Adventures #4~#6 Model CS-4522 | 1981 | Creative Computing Soft. |
| Atari 400/800 cass. | Air Traffic Controller Model CS-7004 | 1981 | Creative Computing Soft. |
| VTECH CreatiVision cart. | Air/Sea Attack Model 8008 | 1981 | VTECH Video Technology, Ltd. |
| Wizzard cart. | Air/Sea Attack Model Y-1660 | 1981 | Dick Smith Electronics |
| Apple II type-in | Aircraft Commander | 1981 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | AIRSIM-1 - Flight Simulator | 1981 | Mind Systems Corp. |
| Video Slot Machine | Ajofrin City | 1981 | R. Franco Recreativos Franco Madrid, Spain |
| Bally Astrocade type-in | Al's Poker Bandit | 1981 | Roginsky, Al |
| Fujitsu FM-8 cass. | Aldebaran Part 1 Model LA-1004 | 1981 | Hudson Soft. Hudson Group Japan |
| Toshiba Pasopia PA7010 cass. | Aldebaran Part 1 Model T-1006 | 1981 | Hudson Soft. Hudson Group Japan |
| Atari 400/800 disk | Ali Baba and the Forty Thieves | 1981 | Quality Soft. Reseda, CA, USA |
| Apple II 5.25 disk | Alibi | 1981 | Hayden Book Co. |
| Apple II 5.25 disk | Alien Ambush | 1981 | Micro Distributors |
| Handheld game | Alien Attack Model 2370 | 1981 | Coleco Industries, Inc. Amsterdam, NY, USA |
| Commodore VIC-20 cart. | Alien Blitz Model 1619 | 1981 | UMI United Microware Industries |
| Applied Technology Microbee cass. | Alien Cresta P | 1981 | Dubois & McNamara Soft. |
| TRS-80 cass. | Alien Cresta | 1981 | Displayed Video Ypsilanti, MI, USA |
| TRS-80 cass. | Alien Defense Mod I & III ver. | 1981 | Soft Sector Marketing, Inc. |
| TRS-80 cass. | Alien Defense Mod I only | 1981 | Soft Sector Marketing, Inc. |
| TRS-80 cass. | Alien Defense Mod III only | 1981 | Soft Sector Marketing, Inc. |
| Atari 400/800 disk | Alien Egg Model APX-20022 | 1981 | APX Atari Program Exchange |
| Atari 400/800 cass. | Alien Hell | 1981 | Syncro |
| Rowtron Television Computer System cart. | Alien Invasion No. 22 | 1981 | Rowtron |
| NEC PC-8001 disk | Alien Part 2 | 1981 | Compaq |
| MB MicroVision game | Alien Raiders | 1981 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Apple II 5.25 disk | Alien Rain | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Apple II 5.25 disk | Alien Typhoon | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Apple II 5.25 disk | Alkemstone Model 10AS2 | 1981 | Level-10 |
| Atari 400/800 disk | Alpha Fighter + Alpha Base | 1981 | DynaComp, Inc. |
| Arcade Video game | Altair | 1981 | Cidelsa Spain |
| Handheld game | Amidar | 1981 | Lansay France |
| Arcade Video game | Amidar Model GX337 | 1981 | Konami Industry Co., Ltd. Japan |
