| RCA COSMAC ELF type-in |  Simon ELF Update | 1981 | Association of Computer Experimenters |
| Bally Astrocade cass. | Simon Says Ver. 3.0 | 1981 | Super Soft. |
| TRS-80 cass. | Simutek II | 1981 | Adventure International |
| Atari 2600 cart. | Skeet Shoot Model AP1001 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Atari 2600 cart. |  Skeet Shoot PAL Model AP-1001 | 1981 | Apollo, Inc. Richardson, TX, USA |
| TRS-80 CoCo cart. | Skiing | 1981 | Tandy Corp. |
| Atari 2600 cart. | Skiing - Le Ski Model CAG-005 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Atari 2600 cart. | Skiing Model PAG-005 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Apple II type-in | Skunk | 1981 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | Sky Blazer | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Arcade Video game | Sky Skipper | 1981 | Nintendo Co., Ltd. Japan |
| TRS-80 disk | Slag Model 011-0018 | 1981 | Adventure International |
| PTC SOL-20 cass. | Slalom P | 1981 | Unknown |
| Atari 400/800 disk | Sleazy Adventure | 1981 | APX Atari Program Exchange |
| Handheld game | Sleep Walker | 1981 | VTECH Video Technology, Ltd. |
| Handheld game | Slimboy Shooting 6 | 1981 | Tomy |
| Handheld game | Slimline Speedway Model 7605 | 1981 | Tomy |
| Atari 400/800 disk | Slip | 1981 | Thorn EMI Video, Ltd. UK |
| Commodore VIC-20 cart. | Slot | 1981 | Commodore, Ltd. |
| Apple II 5.25 disk | Snack Attack | 1981 | Datamost, Inc. |
| Mattel Intellivision cart. | Snafu Model 3758 | 1981 | Mattel Electronics Mattel, Inc. |
| Sharp MZ-80K type-in | Snake Adventure | 1981 | Seibundo Shinkosha Japan |
| Apple II 5.25 disk | Snake Byte | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Sharp MZ-80K type-in | Snakey | 1981 | Kohgaku-Sha Co.,Ltd. |
| Arcade Video game | Snap Jack | 1981 | Universal Co., Ltd Tokyo, Japan |
| Apple II 5.25 disk | Sneakers | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Atari 400/800 disk | Sneakers | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Apple II 5.25 disk | Snoggle | 1981 | Broderbund Soft., Inc. CA, USA 47956 |
| Atari 400/800 disk | Snooker | 1981 | Thorn EMI Video, Ltd. UK |
| Coleco Total Control 4 cart. | Soccer | 1981 | Coleco Industries, Inc. Amsterdam, NY, USA |
| Handheld game | Soccer 2 Model HG-821 | 1981 | Tommy |
| Apple II 5.25 disk | Softporn Adventure | 1981 | On-Line Systems USA |
| Atari 400/800 disk | Softporn Adventure | 1981 | On-Line Systems USA |
| TRS-80 cass. | Softside April CV | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 cass. | Softside April CV | 1981 | SoftSide Publications, Inc. |
| Apple II cass. | Softside April CV | 1981 | SoftSide Publications, Inc. |
| TRS-80 disk | Softside April DV | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 disk | Softside April DV | 1981 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | Softside April DV | 1981 | SoftSide Publications, Inc. |
| Apple II cass. | Softside August CV | 1981 | SoftSide Publications, Inc. |
