| Sharp MZ-80K type-in |  Mogura-Tataki | 1981 | Dempa Shinbunsha Japan |
| Sinclair ZX-81 type-in | Mole | 1981 | EMAP East Midlands Allied Press |
| Commodore VIC-20 cart. | Mole Attack | 1981 | Commodore, Ltd. |
| Atari 400/800 disk | Monarch | 1981 | DynaComp, Inc. |
| Handheld game | Monkey | 1981 | VTECH Video Technology, Ltd. |
| Handheld game | Monkey Business Model 8108 | 1981 | Bandai Co., Ltd. Japan |
| Tabletop game | Monkey Jump Model 31168 | 1981 | Cheryco Japan |
| Phillips Videopac cart. | Monkeyshines Model 37 | 1981 | Philips Corp. |
| Magnavox Odyssey² cart. | Monkeyshines! Model AB9432 | 1981 | Philips Corp. |
| Bally Astrocade type-in | Monster Chase | 1981 | Cursor Group, The |
| Tabletop game | Monster Maze | 1981 | Actronics |
| TRS-80 disk | Monster Maze Model 26-3081 | 1981 | Tandy Corp. |
| Rowtron Television Computer System cart. | Monster Munchers No. 26 | 1981 | Rowtron |
| Handheld game | Monster Panic Model 36520 | 1981 | Epoch Co., Ltd. Tokyo, Japan |
| Apple II 5.25 disk | Monty Plays Scrabble Ver.2 | 1981 | Ritam Corp. |
| Arcade Video game | Monza GP | 1981 | Olympia Milan, Italy |
| Arcade Video game | Moon Base Zeta | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Arcade Video game |  Moon Cresta | 1981 | Game World, Ltd. Nottingham, England |
| Sord M.5 cart. | Moon Patrol P | 1981 | Sord Computer Corp. Japan |
| Arcade Video game | Moon Pulser | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Nascom cass. | Moon Raider | 1981 | Program Power |
| Arcade Video game | Moon Shuttle Model MS-18001 | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Arcade Video game | Moon Shuttle Model MS-28001 | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Arcade Video game | Moon Shuttle Model MSA-8001 | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Arcade Video game | Moon Shuttle Model MSC-8001 | 1981 | Nichibutsu Nihon Bussan Co., Ltd. Osaka, Japan |
| Arcade Video game | Moon Shuttle Taito Upright Model | 1981 | Taito America Corp. Elk Grove Village, IL, USA |
| Arcade Video game | Moon Shuttle Trimline Model | 1981 | Taito America Corp. Elk Grove Village, IL, USA |
| Sharp MZ-80K type-in | Moon UFO | 1981 | Dempa Shinbunsha Japan |
| Atari 400/800 disk | Moonprobe | 1981 | DynaComp, Inc. |
| Arcade Video game | Moonwar | 1981 | Stern Electronics, Inc. Elk Grove Village, IL, USA |
| Apple II 5.25 disk | Moptown | 1981 | Apple Computer, Inc. |
| Apple II 5.25 disk | Moptown Hotel | 1981 | Learning Co., The |
| Apple II 5.25 disk | Moptown Parade | 1981 | Learning Co., The |
| Applied Concepts Great Game Machine mod. | Morphy Edition - Master Chess | 1981 | Applied Concepts, Inc. |
| Coin-op Misc. game | Morskoy Boy | 1981 | Device Automat Russia |
| National JR-100 type-in | Mountain Climbing | 1981 | Unknown |
| Arcade Video game | Mousetrap | 1981 | Exidy, Inc. Sunnyvale, CA, USA |
| Atari 400/800 disk | Mouskattack | 1981 | On-Line Systems USA |
| Atari 400/800 disk | Moutain Shoot Model 051-0079 | 1981 | Adventure International |
| Apple II 5.25 disk | Moving Maze | 1981 | DynaComp, Inc. |
