| Atari 400/800 cass. |  Match Racer | 1981 | Gebelli Soft. |
| Fruit Machine | Match Up | 1981 | Barcrest Games |
| Apple II type-in | Math Decathlon | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 disk | Math Games + Chase Games Model CS-7505 | 1981 | Creative Computing Soft. |
| Atari 400/800 cass. | Math Games Model CS-7005 | 1981 | Creative Computing Soft. |
| Atari 400/800 cass. | MathemaTic-Tac-Toe Model APX 10082 C | 1981 | Atari PECF Creteil, France |
| Atari 400/800 disk | MathemaTic-Tac-Toe Model APX 20082 D | 1981 | Atari PECF Creteil, France |
| Arcade Video game | Mayday!! | 1981 | Hoei International, Inc. Japan |
| Sharp MZ-80K type-in | Maze | 1981 | Kosaido Publishing |
| Arcade Video game |  Maze Invaders | 1981 | Atari, Inc. CA, USA |
| Apple II type-in | Maze Search | 1981 | SoftSide Publications, Inc. |
| Sinclair ZX-81 cass. | Mazogs | 1981 | Bug-Byte London, England |
| Pinball | Medusa Model 1245 | 1981 | Bally Mfg. Co. Chicago, IL, USA |
| Arcade Video game | Megatack | 1981 | Centuri, Inc. Hialeah, FL, USA |
| TRS-80 type-in | Melody Dice | 1981 | SoftSide Publications, Inc. |
| Apple II type-in | Melody Dice | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Melody Dice | 1981 | SoftSide Publications, Inc. |
| VC 4000 cart. | Memory II Cassette No. 20 | 1981 | Interton Electronic |
| Atari 400/800 disk | Memory Match | 1981 | APX Atari Program Exchange |
| Handheld game | Memory Match Model 60-2122 | 1981 | Tandy Corp. |
| Chess board | Mephisto 1X | 1981 | Hegener + Glaser AG |
| Chess board | Mephisto ESB II | 1981 | Hegener + Glaser AG |
| Chess board | Mephisto II | 1981 | Hegener + Glaser AG |
| Slot Machine | Merkur Tahiti | 1981 | ADP Merkur GmbH Gauselmann Group Germany |
| Bally Astrocade type-in | Message from the Lost Tribe | 1981 | Cursor Group, The |
| Atari 400/800 type-in | Messiah | 1981 | SoftSide Publications, Inc. |
| Pinball | Meteor | 1981 | Taito do Brazil |
| Applied Technology Microbee cass. | Meteor Mission 2 | 1981 | Big Five Soft. Van Nuys, CA, USA |
| Bally Astrocade type-in | Meteoroid | 1981 | L&M Soft. Newburgh, IN, USA |
| Arcade Video game |  Meteoroids | 1981 | Venture Line, Inc. Phoenix, AZ, USA |
| Apple II 5.25 disk | Meteoroids in Space | 1981 | Quality Soft. Reseda, CA, USA |
| Arcade Video game | Meteors | 1981 | Amusement World |
| VC 4000 cart. | Metropolis Cassette No. 29 | 1981 | Interton Electronic |
| Handheld game | Mickey Mouse Model MC-25 | 1981 | Nintendo Co., Ltd. Japan |
| Chess board | Micro Chess | 1981 | NOVAG |
| TRS-80 CoCo cart. | Microbes | 1981 | Tandy Corp. |
| IBM PC 5.25in. disk | Microsoft Adventure | 1981 | IBM Corp. International Business Machines |
| Apple II 5.25 disk | Midnight Malady | 1981 | Softsmith Soft. |
| Apple II 5.25 disk | Midnight Malady | 1981 | Softsmith Soft. |
| Exidy Sorcerer cass. | Military Encounter | 1981 | Global Soft. Network |
