| Sinclair ZX-81 cass. |  Lap Record | 1981 | Macronics Systems |
| Audio Sonic PP-1292 cart. | Laser Attack | 1981 | Audio Sonic |
| Arcade Video game |  Laser Base | 1981 | Amstar Electronics Corp. Phoenix, AZ, USA |
| Arcade Video game | Laser Battle | 1981 | Zaccaria Bologna, Italy |
| Atari 2600 cart. | Laser Blast Model AG-008 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Atari 2600 cart. | Laser Blast Model PAG-008 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| TRS-80 cass. | Laser Defense | 1981 | Med Systems |
| Atari 2600 cart. | Lasso-Helden Model 711 011-715 | 1981 | Ariolasoft Germany |
| Handheld game | Lasvegas | 1981 | Bandai Co., Ltd. Japan |
| Arcade Video game | Lazarian Model 636 | 1981 | Bally Midway Mfg. Co. Franklin Park, IL, USA |
| Arcade Video game | Lazarian Model 641 | 1981 | Bally Midway Mfg. Co. Franklin Park, IL, USA |
| Arcade Video game | Lazarian Model 646 | 1981 | Bally Midway Mfg. Co. Franklin Park, IL, USA |
| Handheld game | LCD Baseball Model 16163 | 1981 | Bandai Co., Ltd. Japan |
| Handheld game | LCD Bowling | 1981 | VTECH Video Technology, Ltd. |
| Apple II 5.25 disk | Le Homard Infernal | 1981 | Saari Paris, France |
| Handheld game | Le Livre Magique | 1981 | Texas Instruments |
| Phillips Videopac cart. | Le Mûr Magique | 1981 | Radiola La Radiotechnique Paris, France |
| Sinclair ZX-81 cass. | Learning Lab | 1981 | Sinclair Research, Ltd. |
| Atari 400/800 disk | Lemonade | 1981 | APX Atari Program Exchange |
| Handheld game | Les Envahisseurs | 1981 | Lansay France |
| Handheld game | Les Envahisseurs | 1981 | Ludotronic France |
| Nascom cass. | Level 9 Surround | 1981 | Level 9 Computing |
| TRS-80 type-in | Leyte | 1981 | SoftSide Publications, Inc. |
| Apple II type-in | Leyte P | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Leyte P | 1981 | SoftSide Publications, Inc. |
| Acorn Atom type-in | Life | 1981 | EMAP East Midlands Allied Press |
| Handheld game | Lightfight Model 4144 | 1981 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Pinball | Lightning | 1981 | Stern Electronics, Inc. Elk Grove Village, IL, USA |
| Arcade Video game | Lil' Hustler | 1981 | Dynamo Corp. Grand Prairie, TX, USA |
| Handheld game | Lion Model LN-08 | 1981 | Nintendo Co., Ltd. Japan |
| Atari 2600 cart. | Lochjaw Model AP2005 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Arcade Video game |  Lock'n'Chase | 1981 | Data East Corp. Japan |
| Arcade Video game | Lock'n'Chase | 1981 | Taito America Corp. Elk Grove Village, IL, USA |
| DECO cass. | Lock'n'Chase Model DT-111 | 1981 | Data East Corp. Japan |
| Pinball | Locomotion | 1981 | Zaccaria Bologna, Italy |
| Handheld game | Long Beach Grand Prix Model 40540 | 1981 | Kenner |
| TRS-80 disk | Lords of Karma Model 40551 | 1981 | Microcomputer Games |
| Apple II 5.25 disk | Lords of Karma Model 40552 | 1981 | Microcomputer Games |
| Atari 400/800 disk | Lords of Karma Model 40553 | 1981 | Microcomputer Games |
| Exidy Sorcerer cass. | Lost Dutchman's Gold | 1981 | Unknown |
