| Pinball |  Hustler | 1981 | LTD Sao Paulo, Brazil |
| Pinball | Hyperball | 1981 | Williams Electronics, Inc. Chicago, IL, USA |
| Arcade Video game |  Hyperspace | 1981 | Atari, Inc. CA, USA |
| Mattel Intellivision cart. | Hypnotic Lights | 1981 | Mattel Electronics Mattel, Inc. |
| PTC SOL-20 cass. | ICBM P | 1981 | Hopkins, Ralph |
| Atari 2600 cart. | Ice Hockey Model AX-012 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Atari 2600 cart. |  Ice Hockey Model EAX-012 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Sharp MZ-80K type-in | Ichiroku Musashi | 1981 | ASCII Corp. Japan |
| Arcade Video game | Imola Grand Prix | 1981 | Bacchilega Video Games srl Imol, BO, Italy |
| Atari 400/800 disk | Imperial Walker | 1981 | Crystalware |
| Sharp MZ-80K type-in | Indian Poker | 1981 | Dempa Shinbunsha Japan |
| Quest Electronics Super ELF type-in | Infestation | 1981 | Quest Electronics |
| Atari 2600 cart. | Infiltrate Model AP2006 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Atari 2600 cart. | Infiltrate PAL Model AP-2006 | 1981 | Apollo, Inc. Richardson, TX, USA |
| Handheld game | Insomnie | 1981 | Ludotronic France |
| Apple II 5.25 disk | Instant Zoo | 1981 | Apple Computer, Inc. |
| VC 4000 cart. | Intelligenz IV/Attacke Cassette No. 21 | 1981 | Interton Electronic |
| Heath/Zenith H8 soft. | Interactive Fiction: Dragons of Hong Kong | 1981 | Evryware |
| TRS-80 disk | Interactive Fiction: Dragons of Hong Kong Model 012-0125 | 1981 | Adventure International |
| TRS-80 disk | Interactive Fiction: His Majesty's Ship Impetuous Model 012-0077 | 1981 | Adventure International |
| Apple II 5.25 disk | Interactive Fiction: His Majesty's Ship Impetuous Model 042-0077 | 1981 | Adventure International |
| Apple II 5.25 disk | Interactive Fiction: Six Micro Stories Model 042-0021 | 1981 | Adventure International |
| TRS-80 Mod.II 8in. disk | Interactive Fictions #1~4 Model 022-0081 | 1981 | Adventure International |
| Sinclair ZX-81 cass. | Intermediate English 1 | 1981 | Rose Cassettes |
| Sinclair ZX-81 cass. | Intermediate English 2 | 1981 | Rose Cassettes |
| Sinclair ZX Spectrum cass. | Intermediate Maths 1 | 1981 | Rose Soft. |
| TRS-80 type-in | International Bridge Contractors | 1981 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | International Gran Prix | 1981 | Riverbank Soft. |
| Atari 400/800 disk | Intruder Alert! | 1981 | DynaComp, Inc. |
| Handheld game | Invader 1000 | 1981 | Gakken Japan |
| Handheld game | Invaders | 1981 | VTECH Video Technology, Ltd. |
| Heath/Zenith H8 soft. | Invaders | 1981 | Software Toolworks, The |
| Compukit UK101 cass. | Invaders | 1981 | Premier Publications |
| Acorn Atom cass. | Invaders | 1981 | Bug-Byte London, England |
| Technosys Aamber Pegasus EPROM | Invaders Ver.1.1 | 1981 | Technosys |
| Technosys Aamber Pegasus EPROM | Invaders Ver.1.2 | 1981 | Technosys |
| Nascom cass. | Invasion Earth | 1981 | Program Power |
| Apple II/TRS-80 disk |  Invasion Orion | 1981 | Automated Simulations, Inc. |
| Atari 800/TRS-80 cass. | Invasion Orion | 1981 | Epyx, Inc. Redwood City, CA, USA |
| Bally Astrocade type-in | Invisible War | 1981 | Fabris, Robert San Jose, CA, USA |
