| Arcade Video game |  Enigma II | 1981 | GPi Game Plan, Inc. IL, USA |
| TRS-80 type-in |  Entrapment | 1981 | EMAP East Midlands Allied Press |
| Handheld game | Envahisseurs 2 Model 3213 | 1981 | Ludotronic France |
| Apple II 5.25 disk | Epoch | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Apple II 5.25 disk | Ernie's Quiz | 1981 | Apple Computer, Inc. |
| Handheld game | Escape | 1981 | VTECH Video Technology, Ltd. |
| Apple II 5.25 disk | Escape from Arcturus | 1981 | Synergistic Soft. Bellevue, WA, USA |
| Apple II 5.25 disk | Escape! | 1981 | SubLOGIC Corp. Champaign, IL, USA |
| Atari 400/800 cass. | European Scene Jigsaw Puzzles Vol. 1 Model THE 11010 P | 1981 | Thorn EMI Video, Ltd. UK |
| Atari 400/800 cass. | European Scene Jigsaw Puzzles Vol. 2 Model THE 11011 P | 1981 | Thorn EMI Video, Ltd. UK |
| Pinball | Excalibur | 1981 | Jeutel Toucy, France |
| Chess board | Executive Chess | 1981 | SciSys |
| PTC SOL-20 cass. | Experimental Advanced version of Startrek P | 1981 | Unknown |
| TRS-80 type-in | Exterminate | 1981 | SoftSide Publications, Inc. |
| Arcade Video game | Face Up 21 | 1981 | GAT Game-A-Tron New Britain, CT, USA |
| Apple II 5.25 disk | Falcons | 1981 | Piccadilly Soft. |
| Sinclair ZX-81 cass. | Family Quiz | 1981 | Sinclair Research, Ltd. |
| Apple II type-in | Famous Sayings Hangman | 1981 | SoftSide Publications, Inc. |
| Arcade Video game | Fantastic Voyage | 1981 | Universal Co., Ltd Tokyo, Japan |
| Arcade Video game | Fantasy | 1981 | SNK Corp. Shin Nihon Kikaku Japan |
| Sinclair ZX-81 cass. | Fantasy Games | 1981 | Sinclair Research, Ltd. |
| Sinclair ZX-81 cass. | Fantasy Games: Perilous Swamp + Sorcerer's Island | 1981 | Psion |
| Atari 400/800 disk | Fantasyland 2041 A.D. | 1981 | Crystalware |
| Apple II 5.25 disk | Fantasyland 2041 A.D. | 1981 | Crystalware |
| Handheld game |  Fantomes Gloutons Model 4830 | 1981 | Ludotronic France |
| Pinball | Fathom Model 1233 | 1981 | Bally Mfg. Co. Chicago, IL, USA |
| Bally Astrocade cart. |  Fawn Dungeon | 1981 | McCleave, Barry |
| Fruit Machine | Fiesta | 1981 | AL Associated Leisure Sales |
| Handheld game | Fire Attack Model ID-29 | 1981 | Nintendo Co., Ltd. Japan |
| Handheld game | Fire Away Model 60-2121 | 1981 | Tandy Corp. |
| Handheld game | Fire Away Model 60-9012 | 1981 | Tandy Corp. |
| Fruit Machine | Fire Cracker | 1981 | Bell-Fruit Mfg. Co., Ltd. B.F.M. UK |
| Handheld game | Fire Model FR-27 | 1981 | Nintendo Co., Ltd. Japan |
| Pinball | Fireball II Model 1219 | 1981 | Bally Mfg. Co. Chicago, IL, USA |
| Atari 400/800 cart. | Firebird | 1981 | Gebelli Soft. |
| Apple II 5.25 disk | Firebird | 1981 | Gebelli Soft. |
| Handheld game | Fishing | 1981 | Gakken Japan |
| Atari 2600 cart. | Fishing Derby Model EAG-004 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Atari 2600 cart. | Fishing Derby Model PAG-004 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Arcade Video game | Fitter Upright model | 1981 | Taito Corp. Japan |
