| Arcade Video game |  Dino Ferrari | 1981 | Bacchilega Video Games srl Imol, BO, Italy |
| TRS-80 CoCo cart. | Dino Wars | 1981 | Tandy Corp. |
| Pinball | Disco Dancing | 1981 | LTD Sao Paulo, Brazil |
| TRS-80 type-in | Divide and Conquer | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 cass. | Do-It-Yourself - Spelling | 1981 | PDI Program Design, Inc. |
| Atari 400/800 type-in | Dodge | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 disk | Dodge Racer | 1981 | Synapse Soft. Corp. |
| Acorn Atom type-in | Dodgems | 1981 | EMAP East Midlands Allied Press |
| Atari 400/800 disk | Dog Daze | 1981 | APX Atari Program Exchange |
| Apple II 5.25 disk | Dogfight II | 1981 | Micro Lab, Inc. |
| TRS-80 type-in | Dominoes | 1981 | SoftSide Publications, Inc. |
| Arcade Video game | Donkey Kong | 1981 | Nintendo Co., Ltd. Japan |
| Arcade Video game |  Donkey Kong | 1981 | Nintendo of America, Inc. USA 45496 |
| Arcade Video game | Donkey Kong Cocktail model | 1981 | Nintendo Co., Ltd. Japan |
| Sinclair ZX-80 cass. | Double Breakout | 1981 | Beam Soft. |
| Fruit Machine | Double It | 1981 | Bell-Fruit Mfg. Co., Ltd. B.F.M. UK |
| Handheld game | Dr. Dental Model 16261 | 1981 | Bandai Co., Ltd. Japan |
| Arcade Video game | Draco | 1981 | Cidelsa Spain |
| Tabletop game | Dracula House | 1981 | Epoch Co., Ltd. Tokyo, Japan |
| Tabletop game | Dracula Model 8210 | 1981 | Epoch Co., Ltd. Tokyo, Japan |
| Tabletop game | Dragon Castel | 1981 | Ludotronic France |
| Tabletop game | Dragon Castle Model 90-0124-00 | 1981 | VTECH Video Technology, Ltd. |
| Commodore PET type-in | Dragon Druggin | 1981 | EMAP East Midlands Allied Press |
| Apple II 5.25 disk | Dragon Fire | 1981 | Level-10 |
| Sinclair ZX-81 cass. | Dragon Maze | 1981 | Macronics Systems |
| TRS-80 disk | Dragonquest Model 26-22100ID | 1981 | Programmer's Guild, The |
| TRS-80 cass. | Dragonquest Model 26-22100IT | 1981 | Programmer's Guild, The |
| Atari 2600 cart. | Dragster Rennen Model 711 001-715 | 1981 | Ariolasoft Germany |
| Atari 2600 cart. | Dragster Model EAG-001 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Atari 2600 cart. | Dragster Model PAG-001 | 1981 | Activision, Inc. Santa Clara, CA, USA 47875 |
| Audio Sonic PP-1292 cart. | Draughts | 1981 | Audio Sonic |
| Rowtron Television Computer System cart. | Draughts No. 21 | 1981 | Rowtron |
| Arcade Video game | Draw Poker | 1981 | ESI Electro Sport, Inc. Costa Mesa, CA, USA |
| Arcade Video game | Draw-Poker 81 Amusement | 1981 | GAT Game-A-Tron New Britain, CT, USA |
| DECO cass. | DS Telejan Model DT-114 | 1981 | Data East Corp. Japan |
| TRS-80 cass. | Duel-N-Droids | 1981 | Acorn Soft. Products, Inc. DC, USA |
| TRS-80 disk | Duel-N-Droids | 1981 | Acorn Soft. Products, Inc. DC, USA |
| Atari 2600 cart. | Duell im Weltall Model 711 008-720 | 1981 | Ariolasoft Germany |
| Handheld game | Dungeons & Dragons Model 5409 | 1981 | Mattel Electronics Mattel, Inc. |
| Atari 400/800 disk | Dunjonquest: Morloc's Tower | 1981 | Automated Simulations, Inc. |
