| TRS-80 type-in |  Dairy Farming | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Dairy Farming P | 1981 | SoftSide Publications, Inc. |
| Handheld game | Dallas | 1981 | Mattel Electronics Mattel, Inc. |
| Arcade Video game | Dambusters | 1981 | SWR South West Research UK |
| Tabletop game | Dame Sensory Challenger | 1981 | Fidelity Electronics |
| VC 4000 cart. | Dame Cassette No. 26 | 1981 | Interton Electronic |
| TRS-80 cass. | Danger in Orbit Model 0237R | 1981 | Instant Soft., Inc. |
| Arcade Video game | Daredevil | 1981 | Model Racing S.p.a. Montemarciano, Italy |
| Bally Astrocade type-in | Daredevil | 1981 | Fabris, Robert San Jose, CA, USA |
| Handheld game | Dark Tower | 1981 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Arcade Video game | Dark Warrior | 1981 | Century Electronics, Ltd. England |
| PTC SOL-20 cass. | Darts | 1981 | Hopkins, Ralph |
| Bally Astrocade type-in | Darts | 1981 | Mead, Bill |
| Apple II type-in | Darts | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 disk | Darts + Tilt Model CS-7506 | 1981 | Creative Computing Soft. |
| Atari 400/800 cass. | Darts Model CS-7011 | 1981 | Creative Computing Soft. |
| Atari 400/800 cart. | Darts Model THD 11002 P | 1981 | Thorn EMI Video, Ltd. UK |
| Atari 2600 cart. |  Das Verrückte Huhn Model 711 009-720 | 1981 | Ariolasoft Germany |
| Apple II 5.25 disk | David's Midnight Magic Model APDSK-2 | 1981 | SubLOGIC Corp. Champaign, IL, USA |
| Apple II 5.25 disk | Decimals and Percent - Decimals Practice Problems | 1981 | Society for Visual Education |
| Arcade Video game | Deep Death | 1981 | Pacific Novelty Mfg., Inc. Marina Del Rey, CA, USA |
| Arcade Video game | Defend the Terra Attack on the Red UFO | 1981 | Uko Corp. Japan |
| Atari 2600 cart. | Defender Model 49-75186 | 1981 | Sears Chicago, IL, USA |
| Atari 2600 cart. | Defender Model CX2609P P | 1981 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Defender Model CX2609 P | 1981 | Atari, Inc. CA, USA |
| Exidy Sorcerer cass. | Defense | 1981 | Unknown |
| Commodore VIC-20 cart. | Deflection P | 1981 | Addcom Electronics |
| Atari 400/800 disk | Deflection + Simon Says Model 051-0078 | 1981 | Adventure International |
| Bally Astrocade type-in | Defuse | 1981 | Fabris, Robert San Jose, CA, USA |
| TRS-80 disk | Demise | 1981 | Acorn Soft. Products, Inc. DC, USA |
| Sharp MZ-80K type-in | Demon Driver | 1981 | IPC Business Press, Ltd. |
| Apple II 5.25 disk | Demon's Forge | 1981 | Saber Soft. |
| Arcade Video game | Demoneye-X | 1981 | Irem Corp. Japan |
| Bally Astrocade type-in | Denominator | 1981 | Fabris, Robert San Jose, CA, USA |
| Sharp MZ-80K type-in | Depth Bomb | 1981 | Kosaido Publishing |
| Bally Astrocade cass. | Diamonds | 1981 | Super Soft. |
| Atari 400/800 disk | Dice Poker | 1981 | APX Atari Program Exchange |
| Tabletop game | Dig N Picman | 1981 | Actronics |
| Bally Astrocade type-in | Digital Couch | 1981 | Fabris, Robert San Jose, CA, USA |
| Apple II 5.25 disk | Dinner on a Disk | 1981 | Softsmith Soft. |
