| CP/M 8in. disk |  Cranston Manor Adventure | 1981 | DynaComp, Inc. |
| Sharp MZ-80K type-in | Crash Game | 1981 | ASCII Corp. Japan |
| Sharp MZ-80K type-in | Crazy Balloon P | 1981 | Kohgaku-Sha Co.,Ltd. |
| VTECH CreatiVision cart. | Crazy Chewy Model 8001 | 1981 | VTECH Video Technology, Ltd. |
| VTECH CreatiVision cart. | Crazy Chicky Model 8001 | 1981 | VTECH Video Technology, Ltd. |
| VTECH Funvision game | Crazy Chicky Model Y-2640 | 1981 | VTECH Video Technology, Ltd. |
| Arcade Video game |  Crazy Climber | 1981 | Taito America Corp. Elk Grove Village, IL, USA |
| Mattel Intellivision cart. |  Crazy Clones | 1981 | Mattel Electronics Mattel, Inc. |
| Handheld game | Crazy Crows | 1981 | Bandai Co., Ltd. Japan |
| PTC SOL-20 cass. | Crazy Eights P | 1981 | Hopkins, Ralph |
| Arcade Video game | Crazy Kong | 1981 | Kyoei Japan |
| Arcade Video game | Crazy Kong - Part II | 1981 | Falcon |
| Arcade Video game | Crazy Otto | 1981 | GCC General Computer Corp. |
| VTECH CreatiVision cart. | Crazy Pucker Model 8001 | 1981 | VTECH Video Technology, Ltd. |
| Apple II 5.25 disk | Creature Venture | 1981 | Highland Computer Services |
| Apple II 5.25 disk | Creature Venture | 1981 | Softsmith Soft. |
| TRS-80 disk | Cribbage 2.0 | 1981 | DynaComp, Inc. |
| TRS-80 cass. | Cribbage 2.0 | 1981 | DynaComp, Inc. |
| Handheld game | Croqu' Fantomes Model 3212 | 1981 | Ludotronic France |
| Handheld game | Cross Highway Model 16195 | 1981 | Bandai Co., Ltd. Japan |
| Apple II 5.25 disk | Crossfire | 1981 | On-Line Systems USA |
| Atari 400/800 disk | Crossfire P | 1981 | On-Line Systems USA |
| Atari 400/800 cass. | Crossfire P | 1981 | Sierra On-Line, Inc. USA 20626 |
| Atari 400/800 cart. | CrossFire Model CFL-202 | 1981 | On-Line Systems USA |
| Commodore VIC-20 cart. | Crossfire Model CFL-401 | 1981 | On-Line Systems USA |
| TRS-80 CoCo cart. | Crosswords Model 26-3082 | 1981 | Tandy Corp. |
| Slot Machine | Crown Jubilee | 1981 | Bergmann & Co., Theodor Hamburg, Germany |
| Apple II 5.25 disk | Crown of Arthain | 1981 | Micro Lab, Inc. |
| Arcade Video game | Crush Roller | 1981 | Kural Electric, Ltd. |
| Apple II 5.25 disk | Crush, Crumble and Chomp! | 1981 | Automated Simulations, Inc. |
| Atari 400/800 disk | Crush, Crumble and Chomp! Model B43 | 1981 | Automated Simulations, Inc. |
| Atari 400/800 cass. | Crypts of Terror | 1981 | Inhome Soft., Inc. |
| Sharp MZ-80K type-in | Cubic Maze X-4 | 1981 | Kohgaku-Sha Co.,Ltd. |
| Apple II 5.25 disk | Customized Alphabet Drills | 1981 | Random House, Inc. |
| Apple II 5.25 disk | Cyborg | 1981 | Sentient Soft. |
| Handheld game | Cycle Race Model 60-2153 | 1981 | Tandy Corp. |
| Apple II 5.25 disk | Cyclod | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Atari 400/800 cass. | Cypher Bowl | 1981 | ArtSci |
| Bally Astrocade type-in | D&D Speedway | 1981 | Fabris, Robert San Jose, CA, USA |
| Handheld game | Daijishin Model 16199 | 1981 | Bandai Co., Ltd. Japan |
