| Apple II 5.25 disk |  Computer Quarterback | 1981 | SSI Strategic Simulations, Inc. 16685 |
| Apple II 5.25 disk | Computer Quarterback Second Edition | 1981 | SSI Strategic Simulations, Inc. 16685 |
| Atari 400/800 disk | Computer Quarterback Ver.2 | 1981 | SSI Strategic Simulations, Inc. 16685 |
| Apple II type-in | Computer Space | 1981 | SoftSide Publications, Inc. |
| Bally Astrocade type-in | Computer Twixt | 1981 | Fabris, Robert San Jose, CA, USA |
| Handheld game | Computerized Arcade Model 60-2159 | 1981 | Tandy Corp. |
| Atari 400/800 type-in | Concentration | 1981 | Compute! Publications, Inc. |
| Bally Astrocade type-in |  Concentration | 1981 | Gordon, Al |
| Handheld game | Condors Model 6659 | 1981 | Ludotronic France |
| Atari 800/Apple II/PET/TRS-80 cass. | Conflict 2500 Model 40701 | 1981 | Microcomputer Games |
| TRS-80 disk | Conflict 2500 Model 40751 | 1981 | Microcomputer Games |
| Apple II 5.25 disk | Conflict 2500 Model 40752 | 1981 | Microcomputer Games |
| Atari 400/800 disk | Conflict 2500 Model 40753 | 1981 | Microcomputer Games |
| Apple II 5.25 disk | Conglomerates Collide | 1981 | Rockroy |
| TRS-80 cass. | Conquest of Chesterwoode Model 010-0122 | 1981 | Adventure International |
| TRS-80 disk | Conquest of Chesterwoode Model 012-0122 | 1981 | Adventure International |
| Phillips Videopac cart. | Conquest of the World Model 41 | 1981 | Philips Corp. |
| Magnavox Odyssey² cart. | Conquest of the World Model AB9431 | 1981 | Philips Corp. |
| TRS-80 type-in | Convoy | 1981 | SoftSide Publications, Inc. |
| Apple II type-in | Convoy | 1981 | SoftSide Publications, Inc. |
| Atari 400/800 type-in | Convoy P | 1981 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | Copts and Robbers | 1981 | Sirius Soft., Inc. Sacramento, CA, USA |
| Sinclair ZX-81 type-in | Cosmax | 1981 | EMAP East Midlands Allied Press |
| Arcade Video game | Cosmic Avenger | 1981 | Universal Co., Ltd Tokyo, Japan |
| Apple II 5.25 disk | Cosmic Combat | 1981 | Highland Computer Services |
| MB MicroVision game | Cosmic hunter | 1981 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Watch game | Cosmic Wars | 1981 | Artron |
| Bally Astrocade cass. | Cosmic Zap | 1981 | Super Soft. |
| Arcade Video game | Cosmikaze | 1981 | GAT Game-A-Tron New Britain, CT, USA |
| Sharp MZ-80K type-in | Cosmo Fight | 1981 | ASCII Corp. Japan |
| Arcade Video game | Cosmos | 1981 | Century Electronics, Ltd. England |
| Handheld game | Cosmos | 1981 | Atari, Inc. CA, USA |
| Bally Astrocade type-in | Count the Boxes | 1981 | Astrocade, Inc. |
| Apple II 5.25 disk | County Fair | 1981 | Datamost, Inc. |
| Texas instrument TI-99/4A cart. | Course Manager | 1981 | Foresman & Co., Scott |
| Pinball | Cowboy Eight Ball | 1981 | LTD Sao Paulo, Brazil |
| Rowtron Television Computer System cart. | Cowboy No. 24 | 1981 | Rowtron |
| Fruit Machine | Crackerjack | 1981 | Bell-Fruit Mfg. Co., Ltd. B.F.M. UK |
| Atari 400/800 disk | Cranston Manor Adventure | 1981 | Artworx Soft. Co., Inc. |
| North Star Horizon disk | Cranston Manor Adventure | 1981 | DynaComp, Inc. |
