| TRS-80 type-in |  Compu-Slot Machine | 1980 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | Computer Air Combat | 1980 | SSI Strategic Simulations, Inc. 16685 |
| Handheld game | Computer Backgammon Model 1777 | 1980 | Mattel Electronics Mattel, Inc. |
| Apple II 5.25 disk | Computer Bismarck | 1980 | SSI Strategic Simulations, Inc. 16685 |
| Handheld game | Computer Chess Model 1992 | 1980 | Mattel Electronics Mattel, Inc. |
| Apple II 5.25 disk | Computer Conflict | 1980 | SSI Strategic Simulations, Inc. 16685 |
| Tabletop game | Computer Matician Model 6010 | 1980 | Vanity Fair Ind., Inc. Melville, NY, USA |
| Apple II 5.25 disk | Computer Napoleonics | 1980 | SSI Strategic Simulations, Inc. 16685 |
| Phillips Videopac cart. | Computer Programmer Model 9 | 1980 | Philips Corp. |
| Dedicated Console | Computer TV Game Model CTG-HC10 P | 1980 | Nintendo Co., Ltd. Japan |
| Handheld game | Computron | 1980 | VTECH Video Technology, Ltd. |
| Apple II type-in | Concentration | 1980 | SoftSide Publications, Inc. |
| TRS-80 type-in | Concentration II | 1980 | SoftSide Publications, Inc. |
| TRS-80 disk | Concentration Model 011-0045 | 1980 | Adventure International |
| Apple II cass. | Coney Island Model CIW-879 | 1980 | Softape |
| Phillips Videopac+ G7400 cart. | Conflit Cosmique | 1980 | Philips Corp. |
| Bally Astrocade cass. | Connect Four | 1980 | Cursor Group, The |
| Bally Astrocade type-in | Connect Four | 1980 | Fabris, Robert San Jose, CA, USA |
| Bally Astrocade type-in | Connect Four II | 1980 | Fabris, Robert San Jose, CA, USA |
| Texas instrument TI-99/4A cart. | Connect Four Model 4965 | 1980 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Apple II type-in | Connect-A-Dot | 1980 | SoftSide Publications, Inc. |
| Bingo | Continental Model 1195 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Commodore PET cass. | Contractions 1 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Contractions 2 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Contractions 3 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Contractions 4 | 1980 | Activity Records, Inc. |
| Pinball | Cosmic | 1980 | Taito do Brazil |
| Handheld game | Cosmic Combat Model 7602 | 1980 | Tomy |
| Phillips Videopac cart. | Cosmic Conflict Model 11 | 1980 | Philips Corp. |
| TRS-80 cass. | Cosmic Fighter | 1980 | Big Five Soft. Van Nuys, CA, USA |
| Applied Technology Microbee cass. | Cosmic Fighter P | 1980 | Big Five Soft. Van Nuys, CA, USA |
| Exidy Sorcerer cass. | Cosmic Fighter P | 1980 | Big Five Soft. Van Nuys, CA, USA |
| TRS-80 disk | Cosmic Intruders | 1980 | Ala Video |
| TRS-80 cass. | Cosmic Patrol Model 0223R | 1980 | Instant Soft., Inc. |
| Pinball | Cosmodrome | 1980 | Bell Games |
| Commodore PET cass. | Count 'Em | 1980 | Micro-Ed, Inc. |
| Pinball | Counterforce Model 656 | 1980 | Gottlieb & Co., D. Chicago, IL, USA |
| Amstrad CPC/PCW disk | CPM 03 | 1980 | Adventure PD London, England |
| Bally Astrocade cass. | Craps | 1980 | Fabris, Robert San Jose, CA, USA |
| Cray-1 soft. | Cray Blitz | 1980 | Cray Research, Inc. |
