| Arcade Video game |  San Francisco | 1980 | Shoei Co., Ltd. |
| Apple II 5.25 disk | Sands of Mars | 1980 | Crystalware |
| Atari 400/800 disk | Sands of Mars | 1980 | Crystalware |
| Arcade Video game | Sasuke vs. Commander | 1980 | SNK Corp. Shin Nihon Kikaku Japan |
| Handheld game | Satisfaction! Model 504 | 1980 | Castle Toy |
| Atari 400/800 disk | Saucer | 1980 | Atari, Inc. CA, USA |
| Apple II cass. | Saucer Invasion + Rocket pilot | 1980 | Softape |
| Quest Electronics Super ELF type-in | Saucer Squasher | 1980 | Quest Electronics |
| Pinball | Scorpion | 1980 | Williams Mfg. Co. Chicago, IL, USA |
| TRS-80 type-in | Scott Adams Backgammon | 1980 | SoftSide Publications, Inc. |
| Atari 400/800 cass. | SCRAM | 1980 | Atari, Inc. CA, USA |
| Atari 400/800 disk | SCRAM | 1980 | Atari, Inc. CA, USA |
| TRS-80 disk | Scramble Model 011-0046 | 1980 | Adventure International |
| Sharp MZ-80K cass. | Scramble Model Z-1055 | 1980 | Hudson Soft. Hudson Group Japan |
| Commodore PET cass. | Scrambled Letters | 1980 | Activity Records, Inc. |
| Sharp MZ-80K type-in | Sea Adventure | 1980 | Kohgaku-Sha Co.,Ltd. |
| Arcade Video game | Sea Battle | 1980 | Zaccaria Bologna, Italy |
| Mattel Intellivision cart. | Sea Battle Model 1818 | 1980 | Mattel Electronics Mattel, Inc. |
| MB MicroVision game | Sea Duel | 1980 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Texas Instruments Speak & Read ext. | Sea Sights | 1980 | Texas Instruments |
| Pinball | Seawitch | 1980 | Stern Electronics, Inc. Elk Grove Village, IL, USA |
| DECO cass. | Sengoku Ninja Tai Model DT-102 | 1980 | Data East Corp. Japan |
| Sharp MZ-80K cass. | Sengoku-gun Model Z-1057 | 1980 | Hudson Soft. Hudson Group Japan |
| Sharp MZ-80K type-in | Sensuikan Gekichin Game | 1980 | Dempa Shinbunsha Japan |
| Pinball | Sexy Girl | 1980 | Arkon Automaten |
| Pinball | Sexy Girl | 1980 | Ranco Automaten Switzerland |
| Pinball | Shark | 1980 | Hankin & Co., A. Newcastle, Australia |
| TRS-80 disk | Shark Attack Model 011-0048 | 1980 | Adventure International |
| Sharp MZ-80K type-in | Sharp Block Kuzushi | 1980 | Dempa Shinbunsha Japan |
| Pinball | Shock | 1980 | Taito do Brazil |
| Arcade Video game | Shougi | 1980 | Alpha Denshi Co., Ltd. Japan |
| Handheld game | Sicom 16 | 1980 | Yonezawa Corp. Japan |
| Bally Astrocade type-in | Sideswipe | 1980 | WaveMakers |
| Pinball | Silverball Mania Model 1157 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Bally Astrocade type-in | Sink the U-Boat | 1980 | L&M Soft. Newburgh, IN, USA |
| Pinball | Skateball Model 1210 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Pinball | Skateboard | 1980 | Inder Madrid, Spain |
| Handheld game | Ski Slalom Model 8290 | 1980 | Mattel Electronics Mattel, Inc. |
| TRS-80 disk | Skiing Model 26-3058 | 1980 | Tandy Corp. |
| Atari 2600 cart. | Skiing Model AG-005 | 1980 | Activision, Inc. Sunnyvale, CA, USA |
