| Bally Astrocade type-in |  Hidden Word Finder | 1980 | Walters, S.L. |
| Commodore PET cass. | Higher Same Lower | 1980 | Micro-Ed, Inc. |
| Handheld game | Hit Scramble | 1980 | Shinsei |
| Texas Instruments Speak & Spell mod. | Homonym Heroes Model CD2310 | 1980 | Texas Instruments |
| Commodore PET cass. | Homonyms 1 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Homonyms 2 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Homonyms 3 | 1980 | Activity Records, Inc. |
| Commodore PET cass. | Homonyms 4 | 1980 | Activity Records, Inc. |
| Bally Astrocade type-in | Horse Race | 1980 | Fabris, Robert San Jose, CA, USA |
| Bally Astrocade type-in | Horserace | 1980 | Fabris, Robert San Jose, CA, USA |
| Pinball | Hotdoggin' Model 1199 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Texas instrument TI-99/4A cart. | Hunt The Wumpus Model PHM 3023 | 1980 | Texas Instruments |
| Coin-op Misc. game | Hunting | 1980 | Kusuno |
| Texas instrument TI-99/4A cart. | Hustle Model PHM 3034 | 1980 | Texas Instruments |
| DECO cass. | HWY Chase Model DT-101 | 1980 | Data East Corp. Japan |
| Apple II 5.25 disk | Hyper Head On | 1980 | Broderbund Soft., Inc. CA, USA 47956 |
| TRS-80 disk | Hyperlight Patrol | 1980 | Fantastic Soft. |
| Handheld game | I Took a Lickin' from a Chicken | 1980 | LJN, Ltd. |
| Handheld game | I.A.N. Invisible Alien Neutralizer Model 1994 | 1980 | Mattel Electronics Mattel, Inc. |
| TRS-80 type-in | ICBM | 1980 | SoftSide Publications, Inc. |
| Commodore PET cass. | Identifying Complete Sentences | 1980 | Micro-Ed, Inc. |
| Motorola 6800 CPU soft. | IGM P | 1980 | Unknown |
| TRS-80 type-in | Imhotep | 1980 | SoftSide Publications, Inc. |
| Apple II type-in | Imhotep P | 1980 | SoftSide Publications, Inc. |
| Sharp MZ-80K type-in | Imomushi to Ari | 1980 | ASCII Corp. Japan |
| Trade Stimulator | Improved Lucky 7 | 1980 | Shelby Agency, Inc. Lexington, KY, USA |
| Arcade Video game | Indian Battle Cocktail model | 1980 | Taito Corp. Japan |
| Arcade Video game | Indian Battle Upright model | 1980 | Taito Corp. Japan |
| Sega SC-3000 cass. | Indiana Jaune + Super Lab Model YE 002 | 1980 | Sprites France |
| Bally Astrocade cass. | Inspector Clue-So | 1980 | Collins, John |
| Chess board | Intelligent Chess | 1980 | SciSys |
| VC 4000 cart. | Intelligenz II Cassette No. 15 | 1980 | Interton Electronic |
| VC 4000 cart. | Intelligenz III Cassette No. 16 | 1980 | Interton Electronic |
| TRS-80 disk | Interactive Fiction: Local Call for Death Model 012-0023 | 1980 | Adventure International |
| TRS-80 disk | Interactive Fiction: Six Micro Stories Model 012-0021 | 1980 | Adventure International |
| TRS-80 Mod.II 8in. disk | Interactive Fictions #1~3 Model 022-0061 | 1980 | Adventure International |
| Apple II cass. | Interlude - The Ultimate Experience | 1980 | Syntonic Soft. Corp. |
| Apple II type-in | Interna-Maze | 1980 | SoftSide Publications, Inc. |
| Arcade Video game |  Intruder | 1980 | GPi Game Plan, Inc. IL, USA |
| Handheld game | Invader | 1980 | Gakken Japan |
