| Arcade Video game |  Eagle Upright model | 1980 | Centuri, Inc. Hialeah, FL, USA |
| Texas instrument TI-99/4A cart. | Early Reading Model PHM 3015 | 1980 | Foresman & Co., Scott |
| Interact Family Computer cass. | Earth Outpost I | 1980 | Micro Video |
| TRS-80 type-in | Earth-Port II | 1980 | SoftSide Publications, Inc. |
| Handheld game | Eddie Kidd's Stunt Bike | 1980 | Tomy |
| Redemption mechanical game | El Circulo | 1980 | Inder Madrid, Spain |
| Mattel Intellivision cart. | Electric Company - Word Fun Model 1122 | 1980 | Mattel Electronics Mattel, Inc. |
| Handheld game | Electron Blaster Model 920 | 1980 | Vanity Fair Ind., Inc. Melville, NY, USA |
| Handheld game | Electronic Baseball 3 | 1980 | Entex Industries, Inc. Compton, CA, USA |
| Handheld game | Electronic Basketball 2 Model 6010 | 1980 | Entex Industries, Inc. Compton, CA, USA |
| Handheld game | Electronic Football | 1980 | Epoch Co., Ltd. Tokyo, Japan |
| Handheld game | Electronic Football 3 Model 6018 | 1980 | Entex Industries, Inc. Compton, CA, USA |
| Handheld game | Electronic Jackpot - Gin Rummy & Black Jack Model 6008 | 1980 | Entex Industries, Inc. Compton, CA, USA |
| Handheld game | Electronic Milton | 1980 | MB Milton Bradley Co. East Longmeadow, MA, USA |
| Radofin 1292 Advanced Programmable Video System cart. | Electronic Pinball | 1980 | Radofin Electronics Germany |
| Phillips Videopac cart. | Electronic Table Football Model 27 | 1980 | Magnavox Co., The Fort Wayne, IN, USA |
| Magnavox Odyssey² cart. | Electronic Table Soccer Model AA9423 | 1980 | Magnavox Co., The Fort Wayne, IN, USA |
| Apple II 5.25 disk | Elementary Vol. 1 Model MECC-A702 | 1980 | MECC Minnesota Educational Computing Corp. |
| Apple II cass. | Enchanted Island | 1980 | Mad Hatter Soft. |
| Sharp MZ-80K type-in | Endless Space Wars | 1980 | Kohgaku-Sha Co.,Ltd. |
| Atari 400/800 cass. | Energy Czar | 1980 | Atari, Inc. CA, USA |
| Atari 400/800 type-in | Engineer | 1980 | SoftSide Publications, Inc. |
| Apple II 5.25 disk | Epyx 3-Pack | 1980 | Automated Simulations, Inc. |
| TRS-80 type-in | Escape | 1980 | SoftSide Publications, Inc. |
| RCA COSMAC ELF type-in | ESP | 1980 | Quest Electronics |
| Pinball | Evil Fight | 1980 | Playmatic, S.A. Spain |
| Arcade Video game | Extra Bases Model 761 | 1980 | Midway Mfg. Co. Schiller Park, IL, USA |
| Arcade Video game |  Extra Bases Model 889 | 1980 | Midway Mfg. Co. Schiller Park, IL, USA |
| Handheld game | Fabulous Fred Model 72155 | 1980 | Mego Corp. |
| Handheld game | Fang die NuB Model 604-008 108 | 1980 | Top-O-Tronic Germany |
| Atari 400/800 cass. | Fastgammon | 1980 | Quality Soft. Reseda, CA, USA |
| Pachinko | Fever | 1980 | Sankyo Tokyo, Japan |
| Apple II cass. | Fighter Pilot Model FDB-1178 | 1980 | Softape |
| Arcade Video game | Final Ranger | 1980 | Hoei International, Inc. Japan |
| Pinball | Fire Action | 1980 | Taito do Brazil |
| Pinball | Fire Mountain | 1980 | Zaccaria Bologna, Italy |
| Handheld game | Fire Model RC-04 | 1980 | Nintendo Co., Ltd. Japan |
| Pinball | Fireball II | 1980 | Bell Games |
| Non-Coin Game | Fireball II Model A614-03000 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Handheld game | Fireman Fireman | 1980 | Mego Corp. |
