| Magnavox Odyssey² cart. |  Desafio Chinês! | 1980 | Philips Corp. |
| Arcade Video game | Destroyer | 1980 | Cidelsa Spain |
| Handheld game | Detective Shoestring | 1980 | Grandstand |
| Arcade Video game | Devil Zone | 1980 | Universal Co., Ltd Tokyo, Japan |
| Arcade Video game | Digger | 1980 | Gremlin Ind, Inc. San Diego, CA, USA |
| Handheld game | Digital Daredevil | 1980 | Tomy |
| TRS-80 disk | Dino Wars Model 26-3057 | 1980 | Tandy Corp. |
| Commodore PET cass. | Direction and Distance | 1980 | Micro-Ed, Inc. |
| Atari 2600 cart. |  Dodge 'Em Model CX2637P | 1980 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Dodge 'Em Model CX2637 | 1980 | Atari, Inc. CA, USA |
| Atari 2600 cart. | Dodger Cars Model 49-75158 | 1980 | Sears Chicago, IL, USA |
| Bally Astrocade cass. | Dog Races | 1980 | Super Soft. |
| Apple II 5.25 disk | Dogfight | 1980 | Micro Lab, Inc. |
| Bally Astrocade cart. | Dogpatch Model 2010 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Slot Machine | Dollar Progressive Model 1202 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Slot Machine | Dollar Progressive Model 1203 | 1980 | Bally Mfg. Co. Chicago, IL, USA |
| Atari 400/800 disk | Domination | 1980 | APX Atari Program Exchange |
| Atari 400/800 disk | Dominoes + Cribbage Model CS-7507 | 1980 | Creative Computing Soft. |
| Atari 400/800 cass. | Dominoes Model CS-7007 | 1980 | Creative Computing Soft. |
| Apple II cass. | Don't Fall | 1980 | Innerglo |
| Apple II 5.25 disk | Doom Cavern + Sorcerer’s Challenge | 1980 | Synergistic Soft. Bellevue, WA, USA |
| Arcade Video game | Dorachan | 1980 | Craul Denshi |
| Handheld game | Doremifa Touch Model E0814 | 1980 | Shinsei |
| Atari 400/800 type-in | Double Cannon | 1980 | SoftSide Publications, Inc. |
| TRS-80 type-in | Dr. Livingston, In Search of... | 1980 | SoftSide Publications, Inc. |
| Atari 2600 cart. | Dragster Model AG-001 | 1980 | Activision, Inc. Sunnyvale, CA, USA |
| Fairchild Channel F cart. | Draw Poker | 1980 | Zircon |
| TRS-80 type-in | Draw Poker | 1980 | SoftSide Publications, Inc. |
| TRS-80 type-in | Duck Hunter | 1980 | SoftSide Publications, Inc. |
| Atari 400/800 cass. | Dungeon Campaign Model 6408 | 1980 | Image Computer Products |
| Apple II 5.25 disk | Dungeon of Doom | 1980 | Argon Games |
| Tabletop game | Dungeons & Dragons - Computer Labyrinth Game | 1980 | Mattel Electronics Mattel, Inc. |
| Bally Astrocade cass. | Dungeons And Dragons Program Package | 1980 | Fabris, Robert San Jose, CA, USA |
| Apple II 5.25 disk | Dunjonquest: Hellfire Warrior | 1980 | Automated Simulations, Inc. |
| TRS-80 cass. | Dunjonquest: Morloc's Tower | 1980 | Automated Simulations, Inc. |
| Commodore PET cass. | Dunjonquest: Morloc's Tower | 1980 | Automated Simulations, Inc. |
| TRS-80 disk | Dunjonquest: Morloc's Tower | 1980 | Automated Simulations, Inc. |
| Apple II cass. | Dunjonquest: The Temple of Apshai | 1980 | Automated Simulations, Inc. |
| IBM PC 5.25in. disk | Dunjonquest: The Temple of Apshai Model 215D | 1980 | Automated Simulations, Inc. |
| Arcade Video game | Eagle Maxi model | 1980 | Centuri, Inc. Hialeah, FL, USA |
