| Sega CD |  Sewer Shark Model T-93015 | 1992 | Sony Imagesoft |
| Sega CD | Shadow of the Beast II Model T-113045 | 1993 | Psygnosis, Ltd. |
| Sega CD | Sherlock Holmes - Consulting Detective | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Sherlock Holmes - Consulting Detective Vol II Model T-4653 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD |  Shining Force CD Model 4656 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Silpheed Model T-4423 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD |  Sister Sonic | 199? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Slam City with Scottie Pippen Model T-162035 | 1994 | Digital Pictures |
| Sega CD | Snatcher Model T-95035 | 1994 | Konami Co., Ltd. Japan |
| Sega CD | Sol-Feace Model T-4404 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Sonic CD Model 063320 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega CD | Sonic CD Model T-4407 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega CD | SoulStar Model T-115035 | 1994 | Core Design, Ltd. |
| Sega CD | Space Ace Model T-121025 | 1994 | ReadySoft, Inc. Canada |
| Sega CD | Star Strike | 2003 | Good Deal Games |
| Sega CD | Star Wars - Rebel Assault Model T-60075 | 1994 | JVC Musical Industries, Inc. |
| Sega CD | StarBlade Model T-14025 | 1994 | NAMCO Hometek, Ltd. USA |
| Sega CD | Stellar-Fire Model T-110025 | 1993 | Dynamix Part of the Sierra Family USA 20626 |
| Sega CD | Supreme Warrior - Ying Heung Model T-162045 | 1994 | Digital Pictures |
| Sega CD | Surgical Strike Model 4435 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Syndicate | 1994 | Unknown |
| Sega CD | The Adventures of Batman & Robin Model 063586 | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega CD | The Adventures of Batman & Robin Model 4432 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | The Adventures of Willy Beamish Model T-6300 P | 1993 | Dynamix Part of the Sierra Family USA 20626 |
| Sega CD | The Amazing Spider-Man vs. The Kingpin Model 4412 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega CD | The Exterminators - Special Edition | 2003 | Good Deal Games |
| Sega CD | The Lawnmower Man Model T-160015 | 1994 | Time Warner Interactive |
| Sega CD | The Masked Rider - Kamen Rider ZO Model 4444 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | The San Diego Zoo Presents... The Animals! A True Multimedia Experience Model T-87015 | 1992 | Software Toolworks, The |
| Sega CD | The Smurfs | 2014 | Good Deal Games |
| Sega CD | The Software Toolworks' Star Wars Chess Model T-87035 | 1993 | Software Toolworks, The |
| Sega CD | The Space Adventure Cobra - The Legendary Bandit Model T-143015 | 1994 | Hudson Soft. Hudson Group Japan |
| Sega CD | The Terminator Model T-70015 | 1993 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega CD | Third World War Model T-22025 | 1994 | Extreme Ent. Group |
| Sega CD | Time Cop | 199? | Unknown |
| Sega CD | Time Gal Model T-6214 P | 1993 | Renovation Products USA |
| Sega CD | Tomcat Alley Model 4429 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega CD | Trivial Pursuit - Interactive Multimedia Game Model T-89015 | 1995 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega CD | Ultraverse Prime | 1994 | Sony Imagesoft |
| Sega CD | Vay Model T-127025 | 1993 | Working Designs |
