| Sega Genesis cart. |  The Pagemaster | 1994 | Fox Interactive |
| Sega Genesis cart. | The Pirates of Dark Water | 1994 | SUNSOFT Kounan, Japan |
| Sega Genesis cart. | The Punisher | 1994 | Capcom Co., Ltd. Japan |
| Sega Genesis cart. |  The Revenge of Shinobi | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | The Simpsons - Bart Vs. The Space Mutants Model T-81026 | 1992 | Flying Edge |
| Sega Genesis cart. | The Simpsons - Bart's Nightmare | 1993 | Flying Edge |
| Sega Genesis cart. |  The Story of Thor Beyond Oasis prototype | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | The Terminator | 1991 | Virgin Games, Ltd. UK 013715 |
| Sega Genesis cart. | The Tick Model T-126026 | 1994 | Fox Interactive |
| Sega Genesis cart. | The Young Indiana Jones Chronicles | 199? | Unknown |
| Sega Genesis cart. | Theme Park Model 7367 | 1995 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Thomas the Tank Engine & Friends | 1993 | T-HQ Soft. |
| Sega Genesis cart. | Thunder Force II | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Thunder Force III Model 18036 | 1990 | Tecno Soft. TechnoSoft Japan |
| Sega Genesis cart. | Thunder Fox | 1991 | Taito Corp. Japan |
| Sega Genesis cart. |  Thunder Paw demo | 2021 | PSCD Games |
| Sega Genesis cart. | Time Killers Model T-100046 | 1996 | Black Pearl |
| Sega Genesis cart. | Time Trax | 1994 | Black Pearl |
| Sega Genesis cart. | TinHead Model T-119236 | 1993 | Ballistic |
| Sega Genesis cart. | Tiny Toon Adventures - Acme All-Stars Model T-95146 | 1994 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | Tiny Toon Adventures - Buster's Hidden Treasure Model T-95036 | 1993 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | TNN Bass Tournament of Champions | 1993 | American Softworks Corp. |
| Sega Genesis cart. | TNN Outdoors Bass Tournament '96 Model T-137066 | 1996 | American Softworks Corp. |
| Sega Genesis cart. | Todd's Adventures in Slime World Model T-49216 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Toe Jam & Earl in Panic on Funkotron Model 1043 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Toe Jam & Earl Model 1020 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Tom and Jerry - Frantic Antics Model T-112016 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Tom Clown | 1993 | Realtec Corp. |
| Sega Genesis cart. | Tom Mason's Dinosaurs for Hire Model 1050 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Tommy Lasorda Baseball | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Tony La Russa Baseball Model 7137 | 1993 | EA Sports |
| Sega Genesis cart. | Top Gear 2 Model T-23066 | 1994 | Vic Tokai, Inc. Torrance, CA, USA |
| Sega Genesis cart. | Toughman Contest Model 7511 | 1995 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Tourmaline Hb | 2021 | RetroSouls |
| Sega Genesis cart. | Toxic Crusaders Model 1037 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Toys Model T-86046 | 1993 | Absolute Ent., Inc. Midland Park, NJ, USA |
| Sega Genesis cart. | Trampoline Terror! Model T-34026 | 1990 | Dreamworks Games |
| Sega Genesis cart. | Traysia Model 49166 | 1992 | Renovation Products USA |
| Sega Genesis cart. | Triple Play '96 Model 7386 | 1995 | EA Sports |
| Sega Genesis cart. | Triple Play Gold Edition Model 7735 | 1996 | EA Sports |
