| Sega Genesis cart. |  Street Smart Model T-24026 P | 1991 | TRECO USA |
| Sega Genesis cart. |  Streets of Rage | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Streets of Rage 2 Model 1054 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Streets of Rage 3 Model 1539 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Strider | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Strider Returns - Journey from Darkness Model T-79036 | 1990 | US Gold, Inc. San Francisco, CA, USA 43175 |
| Sega Genesis cart. | SubTerrania Model 1551 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Summer Challenge Model ACLD013 | 1993 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Genesis cart. | Sumo Slam | 2015 | Piko Interactive LLC |
| Sega Genesis cart. | Sunset Riders Model T-95026 | 1992 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | Super 3D Noah's Ark P | 2017 | Piko Interactive LLC |
| Sega Genesis cart. | Super Battleship | 1993 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| Sega Genesis cart. | Super Hang-On | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Super Heavy Duty Hb | 2020 | Playnautic |
| Sega Genesis cart. |  Super Heavy Duty - Preview version | 2020 | Playnautic |
| Sega Genesis cart. | Super High Impact Model T-81146 | 1992 | Arena Ent. |
| Sega Genesis cart. | Super Hydlide Model T-35016 | 1989 | Seismic, Inc. Santa Clara, CA, USA |
| Sega Genesis cart. | Super Monaco GP Model 1107 | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Super Off Road | 1992 | Tradewest, Inc. Corsicana, TX, USA |
| Sega Genesis cart. |  Super Skidmarks | 1995 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Genesis cart. | Super Smash T.V. Model T-81066 P | 1992 | Flying Edge |
| Sega Genesis cart. | Super Spin | 1993 | Zyrinx |
| Sega Genesis cart. | Super Street Fighter II - The New Challengers Model T-12056 | 1994 | Capcom USA, Inc. Santa Clara, CA, USA 13388 |
| Sega Genesis cart. | Super Thunder Blade | 1989 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Super Volleyball | 1991 | Video System Co., Ltd. Kyoto, Japan |
| Sega Genesis cart. | Superman Model T-15036 | 1992 | SUNSOFT Sun Corp. of America IL, USA |
| Sega Genesis cart. | Swamp Thing | 1991 | NuVision |
| Sega Genesis cart. | Switchblade | 2019 | Piko Interactive LLC |
| Sega Genesis cart. | Sword of Sodan Model 7026 P | 1990 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Sword of Vermilion | 1990 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Syd of Valis | 1992 | Renovation Products USA |
| Sega Genesis cart. | Sylvester and Tweety in Cagey Capers Model T-48346 | 1993 | Time Warner Interactive |
| Sega Genesis cart. | Syndicate Model 7368 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | T2 - Terminator 2 - Judgment Day | 1991 | Flying Edge |
| Sega Genesis cart. | T2 - The Arcade Game Model T-81156 P | 1992 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Tanglewood | 2018 | GOG sp. z o.o. |
| Sega Genesis cart. | Tanglewood Hb | 2018 | Big Evil Corp. |
| Sega Genesis cart. | Tanglewood demo | 2018 | Big Evil Corp. |
| Sega Genesis cart. | Target Earth Model 6102 | 1990 | Dreamworks Games |
| Sega Genesis cart. | Task Force Harrier EX | 1991 | TRECO USA |
